Patients with hypogammaglobulinaemia should be examined for responses to T-dependent and T-independent antigens [11, 12].
Hypogammaglobulinaemia is the most common immunodeficiency in CLL and occurs in more than 85% patients at some point during the disease  and in 25% of newly diagnosed patients .
The prognostic significance of hypogammaglobulinaemia in terms of morbidity, mortality, and overall survival of CLL patients remains controversial.
* Prophylactic immunoglobulin is not routinely recommended but may be useful in patients with severe, recurrent bacterial infections and hypogammaglobulinaemia
The signs and symptoms of CVID include hypogammaglobulinaemia (IgG, IgA, and/or IgM), poor titre response to vaccination with polysaccharide and protein antigens (e.g.
Generally, the diagnosis of CVID can be made by demonstrating hypogammaglobulinaemia together with poor or absent response to immunization and characteristic clinical manifestation.
In conclusion, common variable immunodeficiency is a primary immunodeficiency characterized by hypogammaglobulinaemia and increased susceptibility to infections.
monoclonal band (or suspicion of a band) requiring IFE for confirmation, or (e) hypogammaglobulinaemia when suppression of the [gamma] region was evident (hypogammaglobulinaemia).
By our standard protocol, all samples in the probable monoclonal band (n = 79) and hypogammaglobulinaemia (n = 19) categories would proceed to serum IFE.
Of particular interest for this study were the 43 patients with abnormal [kappa]/[lambda] ratios (low ratio: n = 1; high ratios: n = 42), but no evidence of monoclonal bands or hypogammaglobulinaemia by SPEP.
Froland, "The spectrum of hepatobiliary disease in primary hypogammaglobulinaemia," Journal of Internal Medicine, vol.
Stanley, "Nodular regenerative hyperplasia related portal hypertension in a patient with hypogammaglobulinaemia.," World Journal of Gastroenterology, vol.