hypocretin


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hypocretin

(hī′pō-krēt′n)
n.
See orexin.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.
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Neutrophils, they discovered, induce monocyte production through release of a factor called CSF-1, and experiments with mice lacking the gene for hypocretin revealed that the hormone controls CSF1 expression, monocyte production and the development of arterial plaques.
"This is a direct demonstration that hypocretin is also an important inflammatory mediator," says Swirski, an associate professor of Radiology at Harvard Medical School.
Whether IVIg could help recover part of the hypocretin dysfunction involved in cataplexy pathophysiology remains speculative.
The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity.
Sakurai, "Orexin and orexin receptors," in In Hypocretins: Integrators of Physiological Functions, deLecea, L.
Hypocretin is a recently-defined neuropeptide and its levels in CSF have been found low in approximately 90% of patients with idiopathic narcolepsy and cataplexy (8).
The report provides comprehensive information on the Orexin Receptor Type 2 (Ox2R or Hypocretin Receptor Type 2 or HCRTR2), targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type.
Narcolepsy with cataplexy (loss of muscle tone) is associated with a hypocretin deficiency, and is an autoimmune disease, explained Thomas Roth, PhD, Henry Ford Hospital, in his overview of sleep disorders.
Hildt, "The adjuvant component a-tocopherol triggers via modulation of Nrf2 the expression and turnover of hypocretin in vitro and its implication to the development of narcolepsy," Vaccine, vol.
Orexin (also called hypocretin) is synthesised in the hypothalamus and released throughout the brain.
The orexin (hypocretin) is an important neurotransmitter in the regulation of sleep-wakefulness and appetite.