endometrial hyperplasia

(redirected from Hyperplasia with atypia)

endometrial hyperplasia

increase in the number of endometrial glands, usually secondary to hyperestrinism; classified as simple hyperplasia, complex hyperplasia, or complex hyperplasia with atypia; the latter may progress to adenocarcinoma.

endometrial hyperplasia

an abnormal condition characterized by overgrowth of the endometrium resulting from sustained stimulation by estrogen (of endogenous or exogenous origin) that is not opposed by progesterone. Estrogen acts as a growth hormone for the endometrium. Through a complex intercellular mechanism, endometrial cells bind estrogen preferentially and undergo changes characteristic of the proliferative phase of the menstrual cycle. If estrogen stimulation continues for 3 to 6 months without periodic cessation or counteractive progesterone stimulation, as occurs in anovulatory or perimenopausal women and in those receiving replacement estrogen without added progestogen, the endometrium becomes abnormally thickened and glandularized. Unremitting estrogen stimulation eventually causes cystic or adenomatous endometrial hyperplasia. The latter is a premalignant lesion that undergoes malignant degeneration in approximately 25% of cases. The causative relationship between estrogen and endometrial hyperplasia is well established; there is some indication but no proof that estrogen also provokes the change from hyperplasia to neoplasia and malignancy. Endometrial hyperplasia often results in abnormal uterine bleeding. Such bleeding, particularly in older women, constitutes an indication for biopsy or curettage of the endometrium to establish histopathological diagnosis and to rule out malignancy. A functioning estrogen-secreting tumor is suspected if the woman is not taking estrogen medication. Progestogen therapy is effective in reversing the abnormal histopathological changes of endometrial hyperplasia. If hyperplasia is adenomatous, hysterectomy is commonly performed.

endometrial hyperplasia

Adenomatous hyperplasia of endometrium Gynecology A premalignant endometrial lesion of older ♀
Endometrial hyperplasia
Hyperplasia without atypia Glands are crowded w/o cytologic atypia; these have a < 2% progress to carcinoma
Simple hyperplasia Glands are not back-to-back
Complex hyperplasia Glands are back-to-back
Hyperplasia with atypia Glands are crowded with cytologic atypia; ± 23% progress to carcinoma

en·do·me·tri·al hy·per·pla·si·a

(en'dō-mē'trē-ăl hī'pĕr-plā'zē-ă)
Increase in the number of endometrial glands, usually secondary to hyperestrinism; classified as simple hyperplasia, complex hyperplasia, or complex hyperplasia with atypia; the latter may progress to adenocarcinoma.
References in periodicals archive ?
4%) patient each of simple and complex hyperplasia with atypia was seen in 31-40 years age group while another one patient (1.
In 2014, the World Health Organizations [1] classification of endometrial hyperplasia changed and was simplified to include two categories, compared with four previously: from with atypia and without (each of those complex or simple) to hyperplasia with atypia or without atypia.
9%) had endometrial hyperplasia without atypia, and 5(5%) had endometrial hyperplasia with atypia.
Endometrial complex hyperplasia with atypia and endometrial intraepithelial neoplasia (EIN) are considered as precursors of Type I endometrioid adenocarcinoma, and endometrial glandular dysplasia is the precursor of Type II carcinoma.
epithelial hyperplasia with atypia (slight, moderate, or severe);
endometrial hyperplasia with atypia, an overgrowth of the uterine lining in which uterine cells contain precancerous changes
Prediction of endometrial cancer in patients with hyperplasia with atypia, with the available markers has not been reliable yet.
Importantly, to date, of the women who have had endometrial biopsies and have been on active drug there has been no evidence of endometrial hyperplasia with atypia, a potential precursor for endometrial cancer.
3% each with simple hyperplasia and simple hyperplasia with atypia.
6 These are: Simple hyperplasia without atypia; Complex hyperplasia without atypia; Simple hyperplasia with atypia; and Complex hyperplasia with atypia.
In comparison to the four categories (simple hyperplasia, complex hyperplasia, simple hyperplasia with atypia, and complex hyperplasia with atypia) that comprise the World Health Organization (WHO) 1994 classification system, proponents of the BH/EIN classification system have shown improved reproducibility in the diagnostic setting.