hypermutation


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hypermutation

(hī'pĕr-myū-tā'shŭn),
A process whereby heavy and light chain genes of the antibody molecule are mutated at a high rate, leading to diversity in the antibody repertoire.
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Primary diffuse large B-cell lymphomas of the central nervous system are targeted by aberrant somatic hypermutation.
Advances in Pathobiology of Primary Central Nervous System Lymphoma
This somatic hypermutation results in a highly responsive pool of B-cells that can be reactivated much more rapidly on the next encounter with their antigen.
Hypersensitivity and anaphylaxis
Other important features include impaired antigen uptake and presentation of antigen by antigen-presenting cells, lower numbers of naive T cells due to thymic involution and a lower diversity of the T cell repertoire, lower numbers of naive B cells, impaired isotype switching, and somatic hypermutation, which leads to weaker antibody responses with lower affinity (6).
Vaccination indications and limits in the elderly
Epidemiological evidence and indirect molecular findings from immunoglobulin heavy chain variable region gene studies suggest that chronic persistent antigen stimulation constitutes a significant pathogenetic mechanism of thyroid NHL (6), (7) Aberrant activity of somatic hypermutation is another mechanism which may contribute to the development of lymphoid malignancies by causing genetic instability and favouring chromosomal translocation (8).
Primary thyroid lymphoma diagnosed during pregnancy: a case report / Gebelik Sirasinda Tani Konmus Primer Tiroid Lenfomasi: Bir Vaka Sunumu
The neoplastic cells in PEL lack surface expression of B-cell markers, such as CD19, CD20, CD79a, and immunoglobulin, they express plasma cell-related markers, such as CD30, CD38, CD45, and CD138, but they also exhibit clonal rearrangement and somatic hypermutation of immunoglobulin genes, suggesting that they originate from post-germinal center B-cells (1), (5), (6), (7).
Human immunodeficiency virus (HIV)-negative and human herpes virus-8 (HHV-8)-positive primary effusion lymphoma: a case report and review of the literature / insan Bagisiklik Yetmezlik Virusu (HIV) Negatif Human Herpes Virus-8 (HHV-8) Pozitif Primer Efuzyon Lenfoma Olgusu ve Literatur Derlemesi
Among its other findings, this study is the first to find that the genomes of breast carcinomas bear regional clusters of hypermutation, termed "kataegis," and that these regions display a prevalence of signature B mutations.
Translating genomics to the clinic: implications of cancer heterogeneity
2004) have suggested that cellular stress responses might provoke hypermutation in the roundworm Caenorhabditis elegans.
How some alien species become invasive. Some ecological, genetic and epigenetic basis for bioinvasions/ Como las especies exoticas se convierten en invasoras. Algunas bases ecologicas, geneticas y epigeneticas para las invasiones/ Como as especies exoticas se convertem em invasoras. Algumas bases ecologicas, geneticas e epigeneticas para as invasoes
Hypermutation as a factor contributing to the acquisition of antimicrobial resistance.
Antibiotic resistance: a global, interdisciplinary concern
The number of clones and hypermutation operation can be respectively defined as:
Pattern synthesis of conformal arrays by a modified particle swarm optimization
Also, biofilm production has been related to the occurrence of genetic events such as hypermutation, transfer of genes and activation of distinct metabolic pathways.
Biofilm production using distinct media and antimicrobial susceptibility profile of Pseudomonas aeruginosa
Meyerhans A, Asjo B, Wain-Hobson S: Selection, Recombination, and G A Hypermutation of Human Immunodeficiency Virus Type 1Genomes: JV (April) 1991: 1779-1788.
AIDS: a designer virus
Somatic hypermutation allow the immune system to explore local areas around a specific antibody by making small steps towards an antibody with higher affinity.
Informative gene selection for clustering gene expression data using a hybrid GA/CSA

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