However, the relationship between hyperhomocysteinemia
and increased risk of vascular disease is still controversial.
might therefore decrease the integrity of the protein matrix of bone, thereby causing bones to become fragile.
Mice deficient in methylenetetrahydrofolate reductase exhibit hyperhomocysteinemia
and decreased methylation capacity, with neuropathology and aortic lipid deposition.
, or elevated levels of total homocysteine (tHcy) in the blood, is an independent risk factor for neural tube defects, vascular diseases and Alzheimer's disease, and is often associated with diseases such as colon cancer, osteoporosis, and Down syndrome.
24) Other studies reported that hyperhomocysteinemia
was an independent risk factor also for vascular thrombosis.
According to one study, 42% of patients with cerebrovascular disease (stroke or near stroke) had hyperhomocysteinemia
, 28% of those with peripheral vascular disease (obstruction of blood vessels, especially in the legs) had elevated levels, and 30% of those with coronary artery disease (obstruction of the heart's own blood supply, the coronary arteries) had elevated homocysteine levels.
Low folate levels can lead to hyperhomocysteinemia
, a risk factor for vascular disease, cancer and cognitive dysfunction.
in End-stage Renal Disease: Prevalence, Etiology, and Potential Relationship to Atherosclerotic Outcomes.
is an independent risk factor for cardiovascular disease such as ischemic disease, stroke and myocardial infarction, and arterial and venous thrombotic events .
4 [micro]mol/L for males) would result in classification of 29% of the participants as having hyperhomocysteinemia
Today, cardiovascular risk factors known to cause endothelial dysfunction such as hypertension, hyperlipidemia, hyperhomocysteinemia
, smoking and diabetes are found to be closely related to increased plasma ADMA levels (4).
The story underlines the necessity of including the measurement of total homocysteine in all patients with unexplained neurological symptoms, particularly because metabolic disorders associated with hyperhomocysteinemia