Inhibition of tumour cell growth by hyperforin
, a novel anticancer drug from St.
The flowers and leaves of SJW contain bioactive ingredients hyperforin
and hypericin that may affect neurotransmitters in the body.
John's Wort extract, which is rich by the flavonol quercetin and nonphenolic hyperforin
, induces CYP3A4 and CYP2C9.
* Prenylated phloro glucinols: hyperforin
John's Wort has been standardized by several brand and have a chemical composition of 0.3% of hypericin and 3-5% hyperforin
, these chemicals are present naturally in the St.
These are naphthodianthrones (hypericin, pseudohypercin), phloroglucinols (hyperforin
, adipherforin), flavonoids (rutin, hyperoside, quercitrin) xanthones and tannins.
content of St John's wort products and drug interactions
(86) St John's wort contains numerous biologically active components, of which flavonoids (rutin, hyperoside, quercetin, and quercitrin), naphthodianthrones (hypericin and pseudohypericin), and acylphloroglucinols (hyperforin
and adhyperforin) are abundant.
Polysaccharides and hyperforin
from the medicinal plant Hypericum perforatum also known as St John's wort stimulated the differentiation of keratinocytes in several studies [324, 325].
Flowering aerial parts are used in many countries for their antidepressant activity, mostly ascribed to the active principles hyperforin
, hypericin, and pseudohypericin [18, 57].
Fedorocko, "Drug membrane transporters and CYP3A4 are affected by hypericin, hyperforin
or aristoforin in colon adenocarcinoma cells," Biomedicine & Pharmacotherapy, vol.
Induction of human CYP2C9 by rifampicin, hyperforin
, and phenobarbital is mediated by the pregnane X receptor.