In some cases, polysaccharides seem to reduce joint hyperextensibility
. There have been isolated case reports of rapid tissue healing phases induced by sulfated polysaccharide-containing red algae, notably in JHS-associated bowel conditions.
Ehlers-Danlos syndromes (EDS) are a clinically and genetically heterogeneous group of heritable connective tissue disorders characterized by joint hypermobility (JH), skin hyperextensibility
, and tissue fragility (1).
Craniosynostosis, dolichostenomelia, proptosis, low-set ears, arachnodactyly, camptodactyly, pes planus, pectus excavatum or carinatum, scoliosis, joint hyperextensibility
or contractures, hydrocephalus, dilatation of lateral ventricles, Chiari 1 malformation may be seen in this syndrome.
EDS is a group of inherited heterogenous multisystem disorders characterized by skin hyperextensibility
, atrophic scarring, joint hypermobility, and generalized tissue fragility .
Since then, additional features of HIES have been recognized and it has since been regarded as a multisystem disorder characterized by chronic eczema, recurrent staphylococcal skin and lungs infections, pneumatocele formation, candidiasis, retained primary teeth, joint hyperextensibility
, low bone density with bone fractures, scoliosis, and craniosynostosis [4, 5].
There were marked pectus excavatum, mild scoliosis, shoulder hyperextensibility
, negative wrist and thumb sign, no arachnodactyly, pes planus, and thin translucent skin over anterior chest and arms with evidence of easy bruising.
Classic EDS is characterized principally by skin involvement (hyperextensibility
and fragility), with joint hypermobility being more common with the more severe classic form (type I).
Hyper IgE Syndrome is associated with immunologic complications such as rash, boils, pneumonia, eczema, and lymphoma while nonimmunologic complications include characteristic facies, retained primary teeth, and joint hyperextensibility
Some marfanoid features were noticed as moderate thoracic kyphoscoliosis, moderate hypermobility of all joints and skin hyperextensibility
, positive thumb and wrist signs.
Anupama and colleagues reported an interesting case of hyper IgE syndrome (multisystem disorder) which is featured by cutaneous abscess, multilple bone fractures, joint hyperextensibility
, high level of IgE, bilateral cervical ribs and may also be associated with deafness.
Ehlers-Danlos syndrome: This is a hereditary collagen disease characterized by fragility of the skin and blood vessels, hyperextensibility
of joints and hyperelasticity of the skin.