hyperemesis gravidarum

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Hyperemesis Gravidarum



Hyperemesis gravidarum means excessive vomiting during pregnancy.


In pregnant women, nausea and vomiting (morning sickness) are common, affecting up to 80% of pregnancies. Hyperemesis, or extreme nausea and excessive vomiting, occur in about 1% of pregnancies. This condition causes uncontrollable vomiting, severe dehydration, and weight loss for the mother. However, hyperemesis gravidarum rarely causes problems for the unborn baby.

Causes and symptoms

The cause of nausea and vomiting during pregnancy is unknown but may be related to the level of certain hormones produced during pregnancy. Hyperemesis is seen more often in first pregnancies and multiple pregnancies (twins, triplets, etc.). The main symptom of hyperemesis is severe vomiting, which causes dehydration and weight loss.


Although many women with morning sickness feel like they are vomiting everything they eat, they continue to gain weight and are not dehydrated; they do not have hyperemesis gravidarum. Women with this condition will start to show signs of starvation, including weight loss. Physical examination and laboratory tests of blood and urine samples will be used to help diagnose the condition. One of the most common tests used to help diagnosis and monitor hyperemesis gravidarum is a test for ketones in the urine. Excessive ketones in the urine (ketonuria) indicate that the body is not using carbohydrates from food as fuel and is inadequately trying to break down fat as fuel. Ketonuria is a sign that the body is beginning to operate in starvation mode.


Hospitalization is often required. Intravenous fluids with substances that help the body conduct nerve signals (electrolytes) may be given to correct the dehydration and excessive acid in the blood (acidosis). Anti-nausea or sedative medications may be given by injection to stop the vomiting. In some cases, oral medication may be prescribed to control the nausea and vomiting while food is reintroduced. If food cannot be tolerated at all, intravenous nutritional supplements may be necessary. Injections of vitamin B6, in particular, may help overcome nutritional deficiencies that often occur.

Alternative treatment

The severe vomiting associated with hyperemesis gravidarum requires medical attention. Milder episodes of nausea or vomiting may be reduced with deep breathing and relaxation exercises. The use of herbal remedies should be done with extreme caution during pregnancy, especially in the first trimester. Natural remedies to reduce nausea include a teaspoon of cider vinegar in a cup of warm water, or tea made from anise (Pinpinella anisum), fennel seed (Foeniculum vulgare), red raspberry (Rubus idaeus), or ginger (Zingiber officinale). Wristbands can be positioned over acupressure points on both wrists. Aromatherapy with lavender, rose, or chamomile can be soothing, as can smelling ground ginger. Homeopathic remedies—which use extremely diluted solutions as treatments—can be safe and effective for controlling symptoms in some women.


In virtually all cases, the pregnancy can continue to the successful delivery of a healthy baby.


Although there is no evidence that hyperemesis gravidarum can be prevented, vomiting during pregnancy sometimes may be lessened. Maintaining a healthy diet, getting adequate sleep, and controlling stress may contribute to prevention or improvement of symptoms. Several strategies may help lessen the nausea and vomiting. Eating dry foods and limiting fluid intake may also be helpful. Small meals should be eaten frequently throughout the day, with a protein snack at night. Eating soda crackers before rising from bed in the morning may help prevent early morning nausea. Iron supplements may cause nausea and can be eliminated until the nausea is controlled. Sitting upright for 45 minutes after meals may also help.



Levy, B. T., and P. L. Brown. "Nausea and Vomiting in Pregnancy." The Virtual Hospital Page. University of Iowa. http://www.vh.org.
"Natural Remedies During Pregnancy: Frequently Asked Questions." Childbirth.Org. http://www.childbirth.org/articles/remedy.html.

Key terms

Ketonuria — The presence of large amount of ketones in the urine. These byproducts of inadequate breakdown of nutrients indicate that the body is in starvation.
Gale Encyclopedia of Medicine. Copyright 2008 The Gale Group, Inc. All rights reserved.


excessive vomiting. adj., adj hyperemet´ic.
hyperemesis gravida´rum excessive and pernicious vomiting during pregnancy, usually in the first trimester, a more serious condition than the simple morning sickness that is common during the first trimester. The exact cause is not known; however, it is thought to be related to trophoblastic activity and production of chorionic gonadotropin and may be aggravated by psychologic factors. It is more common in association with hydatidiform mole and multiple gestation, both of which are associated with elevated levels of chorionic gonadotropin.
Symptoms. The patient complains of uncontrollable nausea, persistent retching and vomiting, inability to take any food by mouth, and exhaustion due to restlessness and lack of sleep. As the condition persists the patient becomes severely dehydrated, develops a fever, and may show signs of peripheral nerve involvement and jaundice. The urine may contain blood, bile, albumin, and ketone bodies as starvation develops. Although hyperemesis gravidarum is rarely fatal, these latter symptoms indicate a grave illness that demands prompt treatment.
Treatment. The physical symptoms of the patient are relieved by intravenous administration of fluids and nutrients and mild sedation to promote rest and relaxation. There is some controversy as to the value of psychotherapy; however, it is generally agreed that the patient will need help in overcoming emotional problems and situational tension if they contribute to the occurrence of the disorder. Dietary treatment may include limiting the intake of liquids, eating a snack of crackers or dry toast before arising, and avoiding excessive fat in the diet.
Patient Care. The hospitalized patient should be placed in a quiet, well-ventilated room that is free from odors or sights that may cause nausea. Fluid intake and output are monitored and mouth care is given frequently. Food and liquids are resumed on a prescribed schedule that gradually progresses to a regular diet. The patient should be encouraged to talk about her feelings if she indicates a desire to do so. The caregivers should be alert to signs of depression or fears of pregnancy, labor, or the responsibilities of motherhood. Recovery is much more likely if the patient is able to vocalize her fears and seek aid in solving any situational or emotional conflicts that may contribute to her illness. Those who care for her should be sympathetic, optimistic, and reassuring in discussing her condition with her.
hyperemesis lacten´tium vomiting by nursing babies.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

hy·per·em·e·sis grav·i·da'r·um

pernicious vomiting in pregnancy.
Farlex Partner Medical Dictionary © Farlex 2012

hyperemesis gravidarum

(hī′pər-ĕm′ĭ-sĭs grăv′ĭ-dâr′əm)
Severe, intractable vomiting during pregnancy, usually in the first trimester.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

hyperemesis gravidarum

Obstetrics A condition that respects no race, parity status or social class, characterized by vomiting in the 1st trimester–3.5/1000 pregnancies, of a severity that may induce renal failure and require hospitalization; if Pt stabilizes, there is no risk of toxemia during later gestation, nor ↑ risk of spontaneous abortion or deformities
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

hy·per·em·e·sis grav·i·darum

(hī'pĕr-em'ĕ-sis grav-ē'dā-rŭm)
Nausea and vomiting during pregnancy severe enough to result in dehydration, acidosis, and weight loss. May require hospitalization; if untreated, can be fatal.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

hyperemesis gravidarum

A condition of excessively severe and protracted sickness and vomiting occurring as one of the complications of pregnancy. Hyperemesis can be dangerous, but admission to hospital, without treatment, is often sufficient to relieve it.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
References in periodicals archive ?
Maternal weight loss associated with hyperemesis gravidarum: A predictor of foetal outcome.
Hyperthyroidism appearing as hyperemesis gravidarum. Arch Intern Med 1983; 143: 2202-3.
Maternal and fetal outcomes in hyperemesis gravidarum. Int J Gynaecol Obstet 1996; 55: 231-5.
Mullin, "Mortality secondary to hyperemesis gravidarum: a case report," Women's Health & Gynecology, vol.
pylori infection was significantly high in the pregnant population with hyperemesis gravidarum accounting 29.6%, and this finding agrees with study conducted in Jeddah, Saudi Arabia, However, in case of Saudi Arabia there was a case control study with hyperemesis gravidarum and without hyperemesis gravidarum [19].
Lead author of the guideline, Dr Manjeet Shehmar, consultant obstetrician and gynaecologist, said: "Women suffering from nausea and vomiting and hyperemesis gravidarum can face a challenging time in early pregnancy.
Kate was admitted to hospital on Monday after developing the condition known as hyperemesis gravidarum.
Her hyperemesis gravidarum - an extreme form of morning sickness - meant she was forced to announce her first pregnancy weeks earlier than planned.
But the announcement also revealed the Duchess is being treated for very acute morning sickness - hyperemesis gravidarum - at a private London hospital.
Kate has been suffering from hyperemesis gravidarum - a severe form of morning sickness - but is due to visit Norway and Sweden with the duke on an official visit early in 2018.
"The duchess' condition is improving but she is still suffering from hyperemesis gravidarum. She is delighted to be able to be here tonight," an aide said.