HLH is a rare, potentially fatal disorder characterized by abnormal macrophages proliferation and hypercytokinemia
Sleep apnea and daytime sleepiness and fatigue: relation to visceral obesity, insulin resistance, and hypercytokinemia
Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia
Vgontzas AN, Papanicolaou DA, Bixler EO, Hopper K, Lotsikas A, Lin HM, Kales A, Chorousos GP Sleep apnea and daytime sleepiness and fatigue: relation to visceral obesity, insulin resistance, and hypercytokinemia
DISCUSSION: HLH is a rare, life threatening hyperinflammatory syndrome, caused by severe hypercytokinemia
due to a highly stimulated but ineffective immune process.
Epithelial dysfunction in influenza may be influenced by hypercytokinemia
and epithelial cell apoptosis.
In addition to hypercytokinemia
, HLH is associated with low or absent natural killer (NK)-cell and cytotoxic T cell activity7.
recently considered the role of hypercytokinemia
in the pathogenesis and as mentioned above, Okumura et al.
results from uncontrolled activation of histiocytes and T cells (8).
Article reviewed: Sleep apnea and daytime sleepiness and fatigue: Related to visceral obesity, insulin resistance, and hypercytokinemia
Hemophagocytic lymphohistiocytosis is related to uncontrolled activation of T-lymphocytes and monocytes that leads to hypercytokinemia
with tumor necrosis factor alpha (TNF-[alpha]), interferon gamma (INF-[gamma]), interleukin (IL) -6, IL-8, IL-10, IL-12 and IL-18.
The scientists' research paper titled, "Th1 and Th17 hypercytokinemia
as early host response signature in severe pandemic influenza" has appeared in the December issue of the Journal of Critical Care.