hyper-IgM syndrome


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hyper-IgM syndrome

an X-linked immunodeficiency disorder with very low serum concentrations of IgG and IgA with a normal or a markedly elevated concentration of polyclonal IgM; secondary to a mutation in the CD40 ligand gene, leading to defective T cell-dependent, B-cell isotope switching affected boys develop recurrent bacterial infections in the first or second years of life.

hyper-IgM syndrome

Hyperimmunoglobulin M syndrome, see there.

hy·per-IgM syn·drome

(hī'pĕr sin'drōm)
An X-linked immunodeficiency disorder with very low serum concentrations of IgG and IgA with a normal or a markedly elevated concentration of polyclonal IgM; affected boys develop recurrent bacterial infections in the first or second year of life.
References in periodicals archive ?
Low IgE levels have been reported in various forms of severe combined immunodeficiency, hyper-IgM syndrome, ataxia telangiectasia, X-linked recessive Bruton agammaglobulinemia, common variable immunodeficiency, transient hypogammaglobulinemia of infancy, and isolated IgE deficiency whose clinical significance is unclear.
The following conditions/diseases may cause the immune system to be compromised and/or suppressed: Transplantation or Immunosuppressant patients, Chemotherapy/Cancer patients, Overwhelming infection, Poor nutrition, AIDS/HIV, Primary Immune Deficiency, Selective IgA Deficiency, Common Variable lmmunodeficiency, X-Linked Agammaglobulinemia, Chronic Granulomatous Disease, Hyper-IgM Syndrome, Severe Combined Immunodeficiency Disease (SCID), and some newborns diabetes.