hyper-IgM syndrome

(redirected from Hyper IgM syndrome)
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hyper-IgM syndrome

an X-linked immunodeficiency disorder with very low serum concentrations of IgG and IgA with a normal or a markedly elevated concentration of polyclonal IgM; secondary to a mutation in the CD40 ligand gene, leading to defective T cell-dependent, B-cell isotope switching affected boys develop recurrent bacterial infections in the first or second years of life.

hyper-IgM syndrome

Hyperimmunoglobulin M syndrome, see there.

hy·per-IgM syn·drome

(hī'pĕr sin'drōm)
An X-linked immunodeficiency disorder with very low serum concentrations of IgG and IgA with a normal or a markedly elevated concentration of polyclonal IgM; affected boys develop recurrent bacterial infections in the first or second year of life.
References in periodicals archive ?
Ochs et al., "The random inactivation of the X chromosome carrying the defective gene responsible for X-linked hyper IgM syndrome (X-HIM) in female carriers of HIGM1," The Journal of Clinical Investigation, vol.
Leanne, 34, and Stephen, 35, of Tasmania, Australia, whose surnames have not been released, had three attempts at IVF before experts were certain they had an embryo without hyper IgM syndrome.
(1-3) The predominant symptomatic forms of PADs are common variable immunodeficiency (CVID), X-linked agammaglobulinemia (XLA), and Hyper IgM syndromes (HIGM).