Tefinostat or CHR-2845 (cyclopentyl 2-((4-([N.sup.1]hydroxyoctanediamido) cyclohexyl) methylamino)-2-phenylacetate) comes under the hydroxamic acid
category used as a particular substrate for hCE-1 (intracellular carboxyl-esterase), whose expression is limited to cells of the family of monocytes/macrophages.
She added the metal complex of N-aryl hydroxamic acid
are helpful on the breast cancer cell line.
Based on their chemical structures, HDAC inhibitors include short-chain fatty acids, hydroxamic acids
, synthetic benzamides, and cyclic peptides, which exhibit various bioactivities and specificities.
Richon, "Cancer biology: Mechanism of antitumour action of vorinostat (suberoylanilide hydroxamic acid
), a novel histone deacetylase inhibitor," British Journal of Cancer, vol.
Table 1: Types of epigenetic drugs: Drugs Class 5-aza-cytidine (azacitidine), Nucleoside DNMTIs 5-aza-2-deoxycytidine (decitabine), 5-fluoro-2-deoxycytidine, Zebularine RG108 Non-Nucleoside DNMTIs MG98 Antisense Oligonucleotides Table 2: HDAC inhibitors: Drugs Class Valproic acid, Aliphatic acids Sodium phenylbutyrate, Pivaloyloxymethyl butyrate, Vorinostat Romidepsin Cyclic peptides Belinostat, Hydroxamic acids
Panobinostat Entinostat, Benzamides Mocetinostat
Zhang, "Preparation and evaluation of tribological properties of cu nanoparticles surface modified by tetradecyl hydroxamic acid
," Tribology Letters, vol.
It may be seen that RCP and ACP are competitive to synthetic ion exchange resin showing adsorption capacities of 7.32 and 7.61 mg/g, respectively, which are higher than that of reported value (6.0 mg/g) on resin with hydroxamic acid
Whiting, "The development and application of ruthenium catalysed oxidations of a hydroxamic acid
and in situ Diels-Alder trapping of the acyl nitroso derivative," Journal of the Chemical Society.
Suberoyl anilide hydroxamic acid
(SAHA) has been through the stages of clinical trials and approved by the U.S.
Johnson et al., "Induction of apoptosis in U937 human leukemia cells by suberoylanilide hydroxamic acid
(SAHA) proceeds through pathways that are regulated by Bcl-2/Bcl-xL, c-Jun, and [p21.sub.C1P1], but independent of p53," Oncogene, vol.
For many years, numerous and diverse types of HDACi have been identified, including short-chain fatty acids such as valporic acid and phenyl butyrate and hydroxamic acid
derivatives such as suberoylanilide hydroxamic acid
(SAHA), 6-(1,3-dioxo-1H, 3Hbenzo[de]isoquinolin-2-yl)-hexanoic acid hydroxyamide (termed scriptaid), and trichostatin A (TSA).