Histopathological findings in cochlear specimens stained with H&E Normal Saline Mercurochrome Gentamicin n:7 n:7 n:7 Hydropic
and vacuolar degeneration in organ of corti 0 3 3 0 3 3 1 2 3 0 2 3 0 3 3 0 2 3 0 3 2 Degeneration in spiral ganglion cells 0 3 3 1 3 2 1 2 3 0 2 3 0 3 3 1 2 2 0 3 2 Hydropic
and vacuolar degeneration in stria vascularis 0 3 2 0 2 3 1 2 3 0 2 2 0 3 3 0 2 3 0 3 2 Organ of corti (Hydropic
and vacuolar degeneration, loss of inner and outer hair cells) Spiral Ganglion (Cytoplasmic and nuclear condensation, loss of nucleus and neurons) Stria Vascularis (Hydropic
and vacuolar degeneration) 0: No degeneration 1: Mild degeneration 2: Moderate degeneration 3: Severe degeneration
These include products of conception specimens with abnormal villous morphology, early nonmolar specimens with prominent trophoblastic hyperplasia, hydropic
abortuses, and androgenetic/biparental mosaic conceptions.
Interestingly, the appearance of hydropic
degeneration in the keratinocytes was diminished at a dose of 30 J/[cm.sup.2] but fragmented nuclei still could be observed.
In overall abnormal venous flow in DV, an absent or reversed a-wave, along with umbilical vein pulsation is strongly associated with fetal demise in hydropic
Caption: Figure 4: Histological changes of the liver: (blue arrow) hepatocytes with hydropic
degeneration; (red arrow) hepatocytes with hyaline degeneration (Mallory corpuscles); (black arrow) pyknotic nuclei.
brasiliensis in acute toxicity (A) and hepatic tissue presenting apoptosis (1), extramedullary hematopoiesis (2), and hydropic
and hepatic degeneration (3) in the animal subject to a dose of 1000 mg/kg of the extract of K.
Histopathologic investigation showed statistically significant differences between the groups in mean congestion, edema, tubular injury, perirenal fat tissue inflammation, and tubular stasis scores in kidney tissue (P < 0.001, P < 0.001, P < 0.001, P < 0.001, and P = 0.048, respectively; Table 1); congestion, edema, neutrophil inflammation, mononuclear inflammation, and emphysematous change scores in the lung (P <0.001, P <0.001, P <0.001, P = 0.030, and P <0.001, respectively; Table 2); congestion, edema, and neutrophil inflammation scores in the stomach (P = 0.008, P = 0.014, and P <0.001, respectively; Table 3); and congestion and hydropic
degeneration scores in the liver (P = 0.029 and P = 0.002, respectively; Table 4).
A higher magnification (inset, x400) showing epithelial parakeratosis, acanthosis, basal cell hydropic
degeneration, and subepithelial predominant lymphocytic infiltrates.
A liver biopsy was done which showed acute hepatitis with interface activity and hydropic
cytoplasmic changes with intermixed chronic inflammation with prominent eosinophil's and scanty neutrophils; these are findings which were more consistent with a drug-induced hepatic injury.
Some hepatocytes were characterized by hydropic
degeneration, cholestasis, and regeneration (Figures 3(a) and 3(b)).
It was first described by John William Ballantyne in 1892 as a condition associated with hydropic
fetus and Rhesus (Rh) alloimmunization .
Caption: Figure 2: Placental section at low power shows hydropic
villi with increased numbers of nucleated red blood cells in the fetal vessels (H&E x100).