Hyaluronate receptor | definition of Hyaluronate receptor by Medical dictionary
CD44 (redirected from Hyaluronate receptor)
a type I transmembrane protein present on T cells, pre-B cells, monocytes, neutrophils, CNS white matter, fibroblasts, skeletal muscle, and medullary thymocytes; facilitates lymphocyte binding to endothelial venules and assists in adhesion.
CD44 A gene on chromosome 11q13 that encodes a cell surface glycoprotein involved in cell–cell interactions, cell adhesion and cell migration, and which is a receptor for hyaluronic acid. CD44 also interacts with other ligands—e.g., osteopontin, collagens and matrix metalloproteinases—and participates in a range of cellular functions including lymphocyte activation, recirculation and homing, haematopoiesis and tumour metastasis.
References in periodicals archive
In vitro hyaluronate promotes cell migration and can stabilize ocular surface epithelial barrier suggesting that it may be directly involved in the process of epithelial repair by activation of the CD44 (the hyaluronate receptor
Underhill, "The interaction of hyaluronate with the cell surface: the hyaluronate receptor
and the core protein," Ciba Foundation symposium, vol.