Hyalgan

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Related to Hyaluronan: chondroitin sulfate, Proteoglycans

Hyalgan®

Orthopecis A hyaluronate used to treat osteoarthritic knee pain in Pts unresponsive to conservative therapy or simple analgesics; it is injected directly into the knee; relief lasts up to 6 months. See Osteoarthritis.
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Hyaluronan synthase 2 protects skin fibroblasts against apoptosis induced by environmental stress.
Mesothelin is not specific for mesothelioma but may act as a marker for malignancy; the hyaluronan content shows the mesothelial phenotype of the tumor.
Reduced expression of the hyaluronan and proteoglycan link proteins in malignant gliomas.
Hyaluronan is a component of the extracellular matrix and is involved in various aspects of mammalian tissue physiology.
In this study, we analyzed the efficiencies of analyzing serum MPF, soluble mesothelin, hyaluronan, osteopontin, and syndecan-1 levels, both individually and in combination, for distinguishing patients with MPM from those with other pleural diseases such as metastatic malignant pleural diseases (MMPDs), benign pleural diseases (BPDs), and benign asbestos pleurisy (BAP) in a research and clinical center located to an area where mesothelioma and other asbestos-related lung diseases are endemic.
Intraarticular hyaluronan injections in the treatment of osteoarthritis: state-of-the-art review.
Via providing a permeability bar to complement complex, the capsule might visor underlying cell-surface compositions which would otherwise be strong stimulate of the alternative pathway [22] and the degradation of hyaluronic acid (hyaluronan, HA) by hyaluronidase .the capsular polysaccharide, which is composed of hyaluronic acid [23].
Abbreviations HA: Hyaluronan PDAC: Pancreatic ductal adenocarcinoma HYALs: Hyaluronidases HMW: High-molecular-weight LMW: Low-molecular-weight sHA: Sulfated hyaluronic acid FBS: Fetal bovine serum.
Abatangelo, "Functions of hyaluronan in wound repair," Wound Repair and Regeneration, vol.
Although we have shown that TSG-6 exerted an antiinflammatory effect that was CD44 dependent, we cannot negate the effect of TSG-6 on modulating hyaluronan (HA) interaction with CD44 [47,48].
In general, polysaccharides such as chitosan, hyaluronan, alginate, and dextran with oxygen rich structures in hydroxyl and ether groups lead to tightly binding polysaccharides to nanoparticles via steric and electrostatic interaction [38].