Evidence for presence of hyaluronan
binding protein on spermatozoa and its possible involvement in sperm function.
is synthesized in the plasma membrane by any one of three homologous enzymes (HAS1, HAS2, HAS3) known as hyaluronan
The research, published in the journal Nature, showed that mole rat hyaluronan
activates a powerful anti-cancer gene called p16 which prevents cells proliferating when too many of them crowd together.
The researchers were also able to identify the specific gene hyaluronan
synthase 2, or HAS2, responsible for the development of HMW-HA.
All hyaluronic acid products except Euflexxa are made with rooster combs, so tell your doctor if you're allergic to chicken or eggs or if you've ever had an allergic reaction to hyaluronan
Disruption of hyaluronan
synthase-2 abrogates normal cardiac morphogenesis and hyaluronan
-mediated transformation of epithelium to mesenchyme.
Commercially available hyaluronan
is either isolated from mammalian tissues or produced in cultured streptococci with average molecular weights ranging from one to six million.
PRAGUE -- Intra-articular injections of autologous conditioned serum reduced symptoms of knee osteoarthritis significantly more than did saline or hyaluronan
injections in the therapy's first controlled clinical trial, Dr.
PRAGUE -- Intra-articular injections of autologous conditioned serum reduced the symptoms of knee osteoarthritis significantly more than did either saline or hyaluronan
injections in the first controlled clinical trial of the therapy, Dr.
While it is abundant in extracellular matrices, hyaluronan
also contributes to tissue hydrodynamics, the movement and proliferation of cells, and participates in a number of cell surface receptor interactions, notably those including its primary receptor, CD44.
5) While the severity of radiographic osteoarthritis appears to influence the probability of response, the comment by Medina et al suggesting lesser effects in older patients is at variance, at least with the observations made by Lohmander et al, (9) who reported that patients older than 60 years with significant symptoms (Lequesne Index [greater than or equal to] 10) were most likely to benefit from hyaluronic acid treatment and confirmed by Puhl (10) in a reanalysis of data from a previously reported hyaluronan
trial showing that patients over the age of 60 years benefited most from hyaluronic acid treatment.
Besides polysaccharides, they cover the other natural polymers cellulose, starch, hyaluronan
, and chitin and chitosan.