Hutchinson-Gilford disease


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pro·ge·ri·a

(prō-jē'rē-ă), [MIM*176670]
A condition of precocious aging with onset at birth or early childhood; characterized by growth retardation, a senile appearance with dry wrinkled skin, total alopecia, and birdlike facies; early occurrence of atherosclerosis in blood vessels and premature death due to coronary artery disease; genetics unclear.
[pro- + G. gēras, old age]

pro·ge·ri·a

(prō-jēr'ē-ă)
A condition in which normal development in the first year is followed by gross retardation of growth, with a senile appearance characterized by dry, wrinkled skin, total alopecia, and birdlike facies; genetics unclear.
Synonym(s): Hutchinson-Gilford disease.
[pro- + G. gēras, old age]

Hutchinson-Gilford disease

(hutch'in-son-gil'ford)
[Sir Jonathan Hutchinson; Hastings Gilford, Brit. physician, 1861–1941.]
Progeria.

Gilford,

Hastings, English physician, 1861-1941.
Hutchinson-Gilford disease - see under Hutchinson, Sir Jonathan
Hutchinson-Gilford syndrome - Synonym(s): Hutchinson-Gilford disease

Hutchinson,

Sir Jonathan, English surgeon and pathologist, 1828-1913.
Hutchinson crescentic notch - the semilunar notch on the incisal edge of Hutchinson teeth, encountered in congenital syphilis.
Hutchinson disease - age-related guttate choroiditis.
Hutchinson facies - the peculiar facial expression produced by drooping eyelids and motionless eyes in external ophthalmoplegia.
Hutchinson freckle - a brown or black mottled, irregularly outlined, slowly enlarging lesion. Synonym(s): lentigo maligna
Hutchinson mask - the sensation experienced in tabetic neurosyphilis as if the face were covered with a mask or with cobwebs.
Hutchinson patch - interstitial or parenchymatous keratitis giving rise to neovascularization of the cornea. Synonym(s): salmon patch
Hutchinson pupil - dilation of the pupil on the side of the lesion as part of a third nerve palsy.
Hutchinson teeth - the teeth of congenital syphilis in which the incisal edge is notched and narrower than the cervical area. Synonym(s): notched teeth; screwdriver teeth; syphilitic teeth
Hutchinson triad - parenchymatous keratitis, labyrinthine disease, and Hutchinson teeth, significant of congenital syphilis.
Hutchinson-Gilford disease - a condition in which normal development in the first year is followed by gross retardation of growth, with dry wrinkled skin, total alopecia, and birdlike facies. Synonym(s): Hutchinson-Gilford syndrome; progeria
Hutchinson-Gilford syndrome - Synonym(s): Hutchinson-Gilford disease