Hurthle cell carcinoma

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Related to Hurthle cell carcinoma: Hurthle cell adenoma


 [kahr″sĭ-no´mah] (pl. carcinomas, carcino´mata)
a malignant new growth made up of epithelial cells tending to infiltrate surrounding tissues and to give rise to metastases. A form of cancer, carcinoma makes up the majority of the cases of malignancy of the breast, uterus, intestinal tract, skin, and tongue.
adenocystic carcinoma (adenoid cystic carcinoma) carcinoma marked by cylinders or bands of hyaline or mucinous stroma separated or surrounded by nests or cords of small epithelial cells, occurring in the mammary and salivary glands, and mucous glands of the respiratory tract. Called also cylindroma.
alveolar carcinoma bronchioloalveolar carcinoma.
basal cell carcinoma the most common form of skin cancer, consisting of an epithelial tumor of the skin originating from neoplastic differentiation of basal cells, rarely metastatic but locally invasive and aggressive. It usually occurs as small pearly nodules or plaques on the face of an older adult, particularly on a sun-exposed area of someone with fair skin. It has been divided into numerous subtypes on the basis of clinical and histological characteristics.
basosquamous carcinoma carcinoma that histologically exhibits both basal and squamous elements.
bronchioalveolar carcinoma (bronchiolar carcinoma) (bronchioloalveolar carcinoma) (bronchoalveolar carcinoma) a variant type of adenocarcinoma of the lung, with columnar to cuboidal epithelial cells lining the alveolar septa and projecting into alveolar spaces in branching papillary formations. Called also alveolar carcinoma or adenocarcinoma and bronchiolar, bronchioloalveolar, or bronchoalveolar adenocarcinoma.
bronchogenic carcinoma any of a large group of carcinomas of the lung, so called because they arise from the epithelium of the bronchial tree. Four primary subtypes are distinguished: adenocarcinoma of the lung, large cell carcinoma, small cell carcinoma, and squamous cell carcinoma.
cholangiocellular carcinoma a rare type of hepatocellular carcinoma arising from the cholangioles, consisting of two layers of cells surrounding a minute lumen. Called also bile duct carcinoma and cholangiocarcinoma.
chorionic carcinoma choriocarcinoma.
colloid carcinoma mucinous carcinoma.
cylindrical cell carcinoma carcinoma in which the cells are cylindrical or nearly so.
embryonal carcinoma a highly malignant germ cell tumor that is a primitive form of carcinoma, probably of primitive embryonal cell derivation; it usually arises in a gonad and may be found either in pure form or as part of a mixed germ cell tumor.
epidermoid carcinoma squamous cell carcinoma.
giant cell carcinoma a poorly differentiated, highly malignant, epithelial neoplasm containing many large multinucleated tumor cells, such as occurs in the lungs.
hepatocellular carcinoma primary carcinoma of the liver cells with hepatomegaly, jaundice, hemoperitoneum, and other symptoms of the presence of an abdominal mass. It is rare in North America and Western Europe but is one of the most common malignancies in parts of sub-Saharan Africa, Southeast Asia, East Asia, and elsewhere. A strong association seems to exist with chronic hepatitis B virus infection.
Hürthle cell carcinoma a malignant Hürthle cell tumor.
carcinoma in si´tu a neoplasm whose tumor cells are confined to the epithelium of origin, without invasion of the basement membrane; the likelihood of subsequent invasive growth is presumed to be high.
large cell carcinoma a type of bronchogenic carcinoma of undifferentiated (anaplastic) cells of large size, a variety of squamous cell carcinoma that has undergone further dedifferentiation.
medullary carcinoma that composed mainly of epithelial elements with little or no stroma.
mucinous carcinoma an adenocarcinoma that produces significant amounts of mucin.
nasopharyngeal carcinoma a malignant tumor arising in the epithelial lining of the nasopharynx, occurring at high frequency in people of Chinese descent. The epstein-barr virus has been implicated as a causative agent.
non–small cell carcinoma a general term comprising all lung carcinomas except small cell carcinoma, and including adenocarcinoma of the lung, large cell carcinoma, and squamous cell carcinoma.
oat cell carcinoma a form of small cell carcinoma in which the cells are round or elongated and slightly larger than lymphocytes; they have scanty cytoplasm and clump poorly.
papillary carcinoma carcinoma in which there are papillary growths that are irregular in nature arising from otherwise normal tissue; it can occur in the thyroid gland, the breast, or the bladder. Called also papillocarcinoma.
renal cell carcinoma carcinoma of the renal parenchyma, composed of tubular cells in varying arrangements; called also clear cell carcinoma.
scirrhous carcinoma carcinoma with a hard structure owing to the formation of dense connective tissue in the stroma. Called also fibrocarcinoma.
carcinoma sim´plex an undifferentiated carcinoma.
small cell carcinoma a common, highly malignant form of bronchogenic carcinoma in the wall of a major bronchus, occurring mainly in middle-aged individuals with a history of tobacco smoking; it is radiosensitive and has small oval undifferentiated cells. Metastasis to the hilum and to mediastinal lymph nodes is common.
spindle cell carcinoma squamous cell carcinoma marked by development of rapidly proliferating spindle cells.
squamous cell carcinoma
1. carcinoma developed from squamous epithelium, having cuboid cells and characterized by keratinization. Initially local and superficial, the lesion may later invade and metastasize.
2. the form occurring in the skin, usually originating in sun-damaged areas or preexisting lesions.
3. in the lung, one of the most common types of bronchogenic carcinoma, generally forming polypoid or sessile masses that obstruct the airways of the bronchi. It usually occurs in middle-aged individuals with a history of smoking. There is frequent invasion of blood and lymphatic vessels with metastasis to regional lymph nodes and other sites. Called also epidermoid carcinoma.
transitional cell carcinoma a malignant tumor arising from a transitional type of stratified epithelium, usually affecting the urinary bladder.
verrucous carcinoma
1. a variety of squamous cell carcinoma that has a predilection for the buccal mucosa but also affects other oral soft tissue and the larynx. It is slow-growing and somewhat invasive.
2. Buschke-Löwenstein tumor, so called because it is histologically similar to the oral lesion.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

Hürth·le cell car·ci·no·ma

a salivary or thyroid carcinoma composed of cells that have eosinophilic cytoplasm.
See also: Hürthle cell adenoma.
Farlex Partner Medical Dictionary © Farlex 2012


Karl W., German histologist, 1860-1945.
Hürthle cell - a large, granular eosinophilic cell derived from thyroid follicular epithelium by accumulation of mitochondria, e.g., in Hashimoto disease. Synonym(s): Askanazy cell
Hürthle cell adenoma - a follicular adenoma of the thyroid in which the epithelium has undergone metaplasia into Hürthle cells.
Hürthle cell carcinoma - Synonym(s): Hürthle cell tumor
Hürthle cell tumor - neoplasm of the thyroid gland. Synonym(s): Hürthle cell carcinoma
Medical Eponyms © Farlex 2012

Hürth·le cell car·ci·no·ma

(hērtlĕ sel kahrsi-nōmă)
Salivary or thyroid carcinoma composed of cells with eosinophilic cytoplasm.
Medical Dictionary for the Dental Professions © Farlex 2012
References in periodicals archive ?
This case is particular due to the young age of our patient with Hurthle cell carcinoma. knowing the 6th decade is the average age for this rare type of thyroid neoplasm.
Genomic dissection of Hurthle cell carcinoma reveals a unique class of thyroid malignancy: J Clin Endocrinol Metab.
The particular advantages of ThyroSeq[R] v3 over ThyroSeq[R] v2 in guiding the extent of thyroid surgery for indeterminate Hurthle cell cytopathology are illustrated by this case report and helped tailor the best treatment for this patient with a Hurthle cell carcinoma who would otherwise have likely needed a completion thyroidectomy.
FA: follicular adenoma; FC: follicular carcinoma; HCA: Hurthle cell adenoma; HCC: Hurthle cell carcinoma; green: negative; red: positive.
Eng et al., "Genomic dissection of Hurthle cell carcinoma reveals a unique class of thyroid malignancy," The Journal of Clinical Endocrinology and Metabolism, vol.
Auersperg, "The role of radioactive iodine in the treatment of Hurthle cell carcinoma of the thyroid," Thyroid, vol.
Malignancy included follicular carcinoma, Hurthle cell carcinoma, papillary carcinoma, medullary carcinoma, and squamous cell carcinoma.
There were 8 cases of widely invasive follicular carcinoma and 38 cases of minimally invasive follicular carcinoma, four of which had morphology of minimally invasive Hurthle cell carcinoma. We observed 4 cases of undifferentiated carcinoma and 8 cases of poorly differentiated carcinoma in our study.
Follow-up surgical excision of these cytologically indeterminate cases may yield a diagnosis of nodular hyperplasia (Figure 5), follicular adenoma, follicular carcinoma (FC; Figure 6), Hurthle cell adenoma (HcA, Figure 7), Hurthle cell carcinoma (HcC), or papillary thyroid carcinoma (PTC), either classic or follicular variant (FV-PTC, Figure 8).
Hurthle cell carcinoma is a better gold standard than Hurthle cell neoplasm for thyroid fine-needle aspirates: defining more consistent and specific cytologic criteria.
In other areas, the glands contained large oncocytic cells marked by abundant, dense eosinophilic cytoplasm and round nuclei with prominent nucleoli, compelling a consideration of metastatic breast carcinoma with apocrine features or even a Hurthle cell carcinoma of the thyroid.
Follicular carcinomas of the thyroid gland, including their oncocytic variant (the so-called Hurthle cell carcinoma), are subdivided into minimally invasive and widely invasive tumors.