Hurthle cell adenoma

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Related to Hurthle cell adenoma: Hurthle cell carcinoma


a benign epithelial tumor in which the cells form recognizable glandular structures or in which the cells are derived from glandular epithelium.
acidophilic adenoma in a classification system formerly used for pituitary adenomas, an adenoma whose cells stain pale pink with acid dyes; most adenomas that secreted excessive amounts of growth hormone were in this group
ACTH-secreting adenoma (adrenocorticotrophic hormone–secreting adenoma) corticotroph adenoma.
basophilic adenoma in a classification system formerly used for pituitary adenomas, an adenoma whose cells stain pale blue with basic dyes; most adenomas that secreted excessive amounts of adrenocorticotrophic hormone were in this group.
chromophobe adenoma (chromophobic adenoma) a pituitary adenoma composed of cells that lack acidophilic or basophilic granules; this is the same entity as the more precisely named null-cell a.
corticotrope adenoma (corticotroph adenoma) a pituitary adenoma made up predominantly of corticotrophs; excessive corticotropin secretion may cause Cushing's disease or Nelson's syndrome. Called also ACTH-secreting or adrenocorticotropic hormone–secreting adenoma and corticotropinoma.
endocrine-active adenoma a pituitary adenoma that secretes excessive amounts of a hormone; see prolactinoma, corticotroph adenoma, gonadotroph adenoma, growth hormone–secreting adenoma, and thyrotroph adenoma. Called also hyperfunctional or hyperfunctioning adenoma.
endocrine-inactive adenoma a pituitary adenoma that does not secrete excessive amounts of any hormone; many null-cell adenomas are of this type. Called also nonfunctional or nonfunctioning adenoma and nonsecreting or nonsecretory adenoma.
gonadotrope adenoma (gonadotroph adenoma) a rare type of pituitary adenoma made up of gonadotroph-like cells that secrete excessive amounts of follicle-stimulating hormone or luteinizing hormone or both; it may cause precocious puberty, visual disturbances, or hypogonadism.
growth hormone–secreting adenoma a pituitary adenoma made up of somatotroph-like cells that secrete excessive amounts of growth hormone; it may cause gigantism in children or acromegaly in adults. Called also somatotrope or somatotroph adenoma and eosinophilic adenoma.
hepatocellular adenoma a large, fleshy, hypervascular tumor of the liver occurring chiefly in women of childbearing age and associated with oral contraceptive use. It is composed of sheets of cells with areas of hemorrhage and necrosis and has a tendency to hemorrhage and rupture; it may become malignant.
Hürthle cell adenoma a benign hürthle cell tumor.
hyperfunctional adenoma (hyperfunctioning adenoma) endocrine-active adenoma.
lactotrope adenoma (lactotroph adenoma) prolactinoma.
liver cell adenoma hepatocellular adenoma.
nonfunctional adenoma (nonfunctioning adenoma) endocrine-inactive adenoma.
nonsecreting adenoma (nonsecretory adenoma) endocrine-inactive adenoma.
null-cell adenoma a pituitary adenoma whose cells give negative results on tests for staining and hormone secretion; although classically they were considered to be composed of sparsely granulated or degranulated (nonfunctioning) cells, some contain functioning cells and may be associated with a hyperpituitary state such as acromegaly or Cushing's syndrome. These tumors are often discovered clinically only when they have grown large and are pressing on surrounding structures. Called also chromophobic adenoma.
pituitary adenoma a benign neoplasm of the anterior pituitary gland; some contain hormone-secreting cells (endocrine-active adenomas) but some are not secretory (endocrine-inactive adenomas).
plurihormonal adenoma an endocrine-active adenoma that secretes more than one kind of hormone.
prolactin cell adenoma (prolactin-secreting adenoma) prolactinoma.
sebaceous adenoma hypertrophy or benign hyperplasia of a sebaceous (oil-secreting) gland.
adenoma seba´ceum nevoid hyperplasia of sebaceous glands, forming multiple yellow papules or nodules on the face. See also nevus.
somatotrope adenoma (somatotroph adenoma) growth hormone–secreting adenoma.
thyroid-stimulating hormone–secreting adenoma thyrotroph adenoma.
thyrotrope adenoma (thyrotroph adenoma) (TSH-secreting adenoma) a rare type of pituitary adenoma made up of thyrotroph-like cells that secrete excess thyrotropin and cause hyperthyroidism; called also thyroid stimulating hormone–secreting adenoma.
villous adenoma a large soft papillary polyp on the mucosa of the large intestine.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

Hürth·le cell ad·e·no·ma

an uncommon type of thyroid tumor characterized by abundant eosinophilic cytoplasm containing numerous mitochondria. Often malignant with widespread metastases; rarely takes up radioiodine.
See also: Hürthle cell carcinoma.
Synonym(s): oncocytic adenoma
Farlex Partner Medical Dictionary © Farlex 2012

Hürth·le cell ad·e·no·ma

(hērt'lĕ sel ad'ĕ-nō'mă)
An uncommon type of thyroid tumor characterized by abundant eosinophilic cytoplasm containing numerous mitochondria. Often malignant with widespread metastases; rarely takes up radioiodine.
Synonym(s): oncocytic adenoma.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012


Karl W., German histologist, 1860-1945.
Hürthle cell - a large, granular eosinophilic cell derived from thyroid follicular epithelium by accumulation of mitochondria, e.g., in Hashimoto disease. Synonym(s): Askanazy cell
Hürthle cell adenoma - a follicular adenoma of the thyroid in which the epithelium has undergone metaplasia into Hürthle cells.
Hürthle cell carcinoma - Synonym(s): Hürthle cell tumor
Hürthle cell tumor - neoplasm of the thyroid gland. Synonym(s): Hürthle cell carcinoma
Medical Eponyms © Farlex 2012
References in periodicals archive ?
Caption: FIGURE 3: Number of positive autophagy-related proteins (a) and autophagy status (b) in follicular adenoma (FA), follicular carcinoma (FC), Hurthle cell adenoma (HCA), and Hurthle cell carcinoma (HCC).
Parameters Total Follicular Hurthle cell P value N = 373 (%) neoplasm neoplasm N = 265 (%) N = 108 (%) Beclin-1 <0.001 Negative 357 (95.7) 265 (100.0) 92 (85.2) Positive 16 (4.3) 0 (0.0) 16 (14.8) LC3A 0.218 Negative 342 (91.7) 240 (90.6) 102 (94.4) Positive 31 (8.3) 25 (9.4) 6 (5.6) LC3B <0.001 Negative 298 (79.9) 265 (100.0) 33 (30.6) Positive 75 (20.1) 0 (0.0) 75 (69.4) p62 <0.001 Negative 143 (38.3) 138 (52.1) 5 (4.6) Positive 230 (61.7) 127 (47.9) 103 (95.4) BNIP3 <0.001 Negative 294 (78.8) 253 (95.5) 41 (38.0) Positive 79 (21.2) 12 (4.5) 67 (62.0) Table 3: Expression of autophagy-related proteins in follicular adenomas, follicular carcinomas, Hurthle cell adenomas, and Hurthle cell carcinomas.
Histologic findings in cases of Hurthle cell adenoma, Hurthle cell carcinoma, and Hashimoto's thyroiditis have been described previously.[14] Briefly, histologic diagnosis of Hurthle cell neoplasm required an identification of an isolated mass in the thyroid composed exclusively of Hurthle cells and found in a gland not affected by chronic thyroiditis.
(%) Histologic Diagnosis of Cases Hurthle cell adenoma 13 (46) Follicular carcinoma 7 (25) Hurthle cell carcinoma 2 (7) Follicular adenoma 3 (11) Adenomatous nodule 3 (11) Total 28
Among the benign lesions which are histologically proved, Hurthle cell adenomas showed increased number and size of AgNORs, when compared to the other type of benign lesions.
Erickson et al (213) evaluated the expression of Ki-67 and cyclin D1 in Hurthle cell neoplasms (59 Hurthle cell adenomas, 55 Hurthle cell carcinomas, and 14 Hurthle cell neoplasms of uncertain malignant potential).