Hürthle cell

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Related to Hurthle cell: Hurthle cell adenoma

Hürth·le cell

a large, granular eosinophilic cell derived from thyroid follicular epithelium by accumulation of mitochondria, for example, in Hashimoto disease.
Synonym(s): Askanazy cell

Hürthle cell

A large granular cell found in pathological sections in some thyroid diseases.


Karl W., German histologist, 1860-1945.
Hürthle cell - a large, granular eosinophilic cell derived from thyroid follicular epithelium by accumulation of mitochondria, e.g., in Hashimoto disease. Synonym(s): Askanazy cell
Hürthle cell adenoma - a follicular adenoma of the thyroid in which the epithelium has undergone metaplasia into Hürthle cells.
Hürthle cell carcinoma - Synonym(s): Hürthle cell tumor
Hürthle cell tumor - neoplasm of the thyroid gland. Synonym(s): Hürthle cell carcinoma

Hürthle cell

large oxyphilic, eosinophilic cells found in the thyroid gland. They are metabolically altered follicular cells which accumulate large numbers of mitochondria. See also Hürthle cell tumor (below).

Hürthle cell tumor
a new growth of the thyroid gland composed wholly or predominantly of large cells (Hürthle cells) having abundant granular, eosinophilic cytoplasm. Such tumors are usually benign (Hürthle cell adenoma) but on occasion may be locally invasive or may rarely metastasize (Hürthle cell carcinoma, or malignant Hürthle cell tumor). Called also oxyphilic adenoma of thyroid gland.
References in periodicals archive ?
Nevertheless, many authors believe that the indeterminate category (especially atypical follicular cells of undetermined significance, but also including suspicious for a follicular/ Hurthle cell neoplasm) is overused.
Prognostic factors of recurrence in encapsulated Hurthle cell carcinoma of the thyroid gland: a clinicopathologic study of 50 cases.
More challenging and controversial is the management of patients with follicular or Hurthle cell neoplasms.
Fine-needle aspiration biopsy of Hurthle cell lesions of the thyroid gland: a cytomorphologic study of 139 cases with statistical analysis.
Of the patients 56% were found to have papillary carcinoma (mixed type included) and 44% follicular carcinoma, including Hurthle cell carcinoma; 82% were low risk (stages I--II according to the TNM system) and 18% high risk (stages III--IV).
Final pathology of the thyroid gland showed follicular carcinoma with Hurthle cell features [Figure 5].
Selenoprotein expression in Hurthle cell carcinomas and in the human Hurthle cell carcinoma line xtc.
While PET-CT has proved itself in this clinical scenario, evidence is emerging on the advantages of PET-CT imaging in other histological types of thyroid malignancy, such as Hurthle cell, medullary, and the anaplastic variants.
We examined 56 FFPE tissue samples from follicular neoplasms for which clinical data and sufficient tissue were available [32 FA, 19 Hurthle cell carcinomas (HCC), and 10 FTC cases].
The new guidelines recommend that PET scans also may be used as part of initial staging in poorly differentiated thyroid cancers and invasive Hurthle cell carcinomas, as a prognostic tool in patients with metastatic disease to identify those patients at highest risk of rapid disease progression and disease-specific mortality, and as an evaluation of posttreatment response following systemic or local therapy of metastatic or locally invasive disease.