Huperzine A is another natural choline esterase inhibitor isolated from the Chinese herb Huperzia
serrata shown to improve cognitive function and general daily activity (Yang et al.
These plants include galantamine, sage, ginkgo, huperzia
, cannabis and yokukansan, among others.
We anticipate this study will help resolve confusion regarding the identity of North American Huperzia
species, particularly among the taxa in the northern and western regions of the continent, which remain poorly understood.
126-128) Herbal cholinergic support may include phosphatidyl choline, pantothenic acid, huperzine A (from Huperzia
serrata), and N-aceytl-L-carnitine.
Huperzine A is a biochemical component of the Chinese club moss Huperzia
Huperzine A (HupA), a cholinesterase inhibitor naturally derived from the Chinese herb Lycopodium serratum (or Huperzia
serrata), has better penetration through the blood-brain barrier, higher oral bioavailability and longer duration of AChE inhibitory action than tacrine, donepezil, and rivastigmine.
It comes from the Chinese club moss, Huperzia
Until now, researchers have only been able to derive small amounts of the compound directly from the Huperzia
serrata plant, or had to resort to lengthy and cumbersome methods to synthesize it in the lab.
(Lycopodiaceae) comprises 300 terrestrial and epiphytic species distributed throughout the world (Ollgaard, 1992) of which some 60 species occur in paramo (Luteyn, 1999).
Cannabaceae Crawford Harrison Huperzia
Zea mays) + Convolvulaceae + Cypemceae + + + + Dipsacaceae + Lamiaceae + Liliaceae + Onagmceae + Poaceae + + + + Polygalaceae + + Polygonaceae + + + + Primulaceae + Ranunculaceae + Rumex + Typhaceae + + + BRYOPHYTA Phaeoceros + + Sphagnum + + PTERIDOPHYTA Alsophila + + + + Anogramma + + + Anemia + + + Blechnum + + + + Botrychium + + + + Cyathea + + + Cyathaceae + + + + Cystopteris + + Dicksonia + + + Dicranoglossum + + + Dicranopteris + + + + Huperzia
+ + + Hymenophyllum + + + Gleichenia + + Lophosoria + + Lycopodiella + + Lycopodium + Lygodium + Marratiaceae + Microgramma + + + + Ophioglossum + Osmunda + + + + Polypodiaceae + Plagiogyria + Pterideae + + + + Schizea + Selaginella + + + + Vittariacae + Figura 5.
This ADCS trial is evaluating whether huperzine A, a natural cholinesterase inhibitor derived from the Chinese herb, Huperzia
serrata, can slow the progression of cognitive decline in people with mild to moderate AD.