Huntington's disease


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Related to Huntington's disease: Parkinson's disease

Huntington's disease

(hŭn′tĭng-tənz)
n.
A rare inherited disease of the central nervous system characterized by progressive dementia, abnormal posture, and involuntary movements. The typical age of onset is between 30 and 50 years. Also called Huntington's chorea.

Huntington's disease

Huntington's chorea Neurology An AD degenerative disease of adult onset–ages 40-50 that leads inexorably to death Clinical Slowly progressive mood and personality changes, mental deterioration, loss of coordination, chorea, cognitive decline, chronic fatigue, apathy Treatment None. See 'Escapee. ', Trinucleotide repeat disease.

Huntington's disease

A rare, dominant, genetic brain disorder caused by a defective gene on chromosome number 4 that has complete penetrance. The disease appears most often in middle-aged adults and leads to loss of nerve cells and a buildup of the neurotransmitter dopamine. This causes involuntary twitching or jerking movements of the face and body (chorea), alternating excitement and depression, and progressive DEMENTIA. The chorea can be controlled by drugs but there is no treatment for the central problem. When the disease starts in childhood the inheritance is four times as likely to be from the father than from the mother. The mechanism of the disease is unknown but it is thought that neural toxicity results from the accumulation of amino-terminal fragments containing an expanded polyglutamine region. (George Huntington, 1850–1916, American General Practitioner)

Huntington's disease

A rare hereditary condition that causes progressive chorea (jerky muscle movements) and mental deterioration that ends in dementia. Huntington's symptoms usually appear in patients in their 40s. There is no effective treatment.
Mentioned in: Movement Disorders
References in periodicals archive ?
The Huntington's disease candidate region exhibits many different haplotypes.
is a non-profit organization pursuing a biotech approach to rapidly discover and develop drugs that prevent or slow Huntington's disease. Through collaborations with academic and industrial partners, CHDI participates in all aspects of drug discovery and development from discovery research through clinical development.
(10.) HDCRG (The Huntington's Disease Collaborative Research Group).
"The second stage of Huntington's disease is often a difficult time period ...
Huntington's disease is a complex genetic condition, and patients with the disease require expert care by a range of health professionals.
Predictive DNA-testing for Huntington's disease and reproductive decision making: a European collaborative study.
The focus is on maintaining the quality of life of the person with Huntington's disease and the maintenance of their independence for as long as possible.
Using the Huntington's disease register for South Wales, a total of 86 affected individuals were identified living in the counties of Mid Glamorgan, South Glamorgan and Gwent, giving a point prevalence rate for Huntington's Disease in South East Wales of 6.2/100 000.
Muscat: A book that was jointly edited by a professor at Sultan Qaboos University and describes types of food that help patients who suffer from Huntington's Disease has won an award at the Gourmand World Cookbook Awards.
Titled, Food for Huntington's Disease the book has won under the category health and nutrition science - institutions.
Neuroscientists at Academia Sinica have identified a key protein that exacerbates brain diseases such as Huntington's disease, which could shed light on future drug development, the institute said Tuesday.
Under the terms of the agreement, Voyager gains worldwide rights to the VY-HTT01 Huntington's disease program and ex-U.S.

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