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Huntington's chorea (disease)[hunt´ing-tunz]
Huntington's choreaan incurable degeneration of the human nervous system characterized by involuntary movements of the head, face and/or limbs, leading to eventual death. The disorder is caused by a single autosomal dominant gene on chromosome 4 (see DOMINANCE that shows delayed penetrance, fewer than 5% of cases being seen before the age of 25. Thus many individuals carrying the dominant allele have reproduced before their own gene shows itself; their progeny in turn may have to wait until middle age to discover if they have inherited the condition. Named after the American neurologist George Huntington (1851–1916).
diseasepathogenic entity characterized by an identifiable aetiological agent, group of signs and symptoms and/or consistent anatomical alterations; see syndrome
Huntington's disease; Huntington's chorea untreatable autosomal-dominant, relentlessly progressive chorea with dementia (due to cerebral atrophy), manifesting in middle life, leading to death within 10-12 years of onset
choreairregular, spasmodic, involuntary movements of limbs or facial muscles
Huntington's chorea; Huntington's disease see disease, Huntington's
Sydenham's chorea; St Vitus' dance acute neurological disorder of young people triggered by group A haemolytic streptococcus infection, causing formation of autoantibodies directed against the basal ganglia; characterized by involuntary, irregular, jerky movements (of facial, neck and limb muscles) which are increased by effort and disappear during sleep