humoral immunity

(redirected from Humoral immune system)
Also found in: Dictionary, Encyclopedia.

hu·mor·al im·mu·ni·ty

immunity associated with circulating antibodies, in contradistinction to cellular immunity. The inherent range of activity of antibody specificities is wide but proliferation of antigen-specific B cells occurs rapidly during infections leading to rapid increases in antibody titers with enhanced affinity for the inciting agent, and a more effective and directed response.

humoral immunity

n.
Immunity involving the transformation of B-lymphocytes into plasma cells that produce and secrete antibodies to a specific antigen.

hu·mor·al im·mu·ni·ty

(hyū'mŏr-ăl i-myū'ni-tē)
Immunity associated with circulating antibodies, in contradistinction to cellular immunity.
Enlarge picture
HUMORAL IMMUNITY

humoral immunity

The protective activities of antibodies against infection or reinfection by common organisms, e.g., streptococci and staphylococci. B lymphocytes with receptors to a specific antigen react when they encounter that antigen by producing plasma cells (which produce antigen-specific antibodies) and memory cells (which enable the body to produce these antibodies quickly in the event that the same antigen appears later). B-cell differentiation also is stimulated by interleukin-2 (IL-2) secreted by CD4+ T cells and foreign antigens processed by macrophages.

Antibodies produced by plasma B cells, found mainly in the blood, spleen, and lymph nodes, neutralize or destroy antigens in several ways. They kill organisms by activating the complement system; neutralize viruses and toxins released by bacteria; coat the antigen (opsonization) or form an antigen-antibody complex to stimulate phagocytosis; promote antigen clumping (agglutination); and prevent the antigen from adhering to host cells.

Synonym: B-cell–mediated immunity See: illustration; cell-mediated immunity; immunoglobulin
See also: immunity
References in periodicals archive ?
Keywords: Chronic inflammation; Cancerogenesis; Cellular immune system; Humoral immune system; Immune homeostasis
The humoral immune system that is mediated by serum antibodies secreted by B cells is one of the major immunological defenses.
The humoral immune system has a key prognostic impact in node-negative brea st cancer
Concerning the mechanism underlying psychologic stress-related oxidant stress described by Chalmers et al., we agree with their hypothesis of the involvement of a chronic elevation of cortisol favoring the development of an innate immune response at the expense of the humoral immune system, which results in chronic inflammatory process and therefore in a high prooxidant state.
Different experimental models use haemagglutination assay to assess the effects on humoral immune system in the mice.
These results can provide us new insights into that calreticulin maybe also activate of the humoral immune system in fat body.