humanized antibody


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humanized antibody

Molecular medicine A recombinant DNA product which ↓ non-human monoclonal antibody immunogenicity, by transferring the hypervariable genes of rodent antibodies–which encode peptide segments capable of recognizing the desired epitope, into normal human genes. Cf Designer antibody.
References in periodicals archive ?
TREATMENT with pembrolizumab, a humanized antibody used in cancer immunotherapy, may affect pigmentation of some benign skin lesions, according to a case study
Palivizumab is a humanized antibody mononklonalne in the form of powder to the solvent for solution for injection.
The company said sacituzumab govitecan is its lead investigational antibody-drug conjugate (ADC) developed by conjugating the moderately-toxic drug, SN-38, site-specifically and at a high ratio of drug to antibody, to a humanized antibody that targets the TROP-2 receptor expressed by many solid cancers.
A humanized antibody In phase III trials Hoffman La Roche, that binds to a for MS Ltd.
Gevokizumab (XOMA 052), a humanized antibody that binds to the inflammatory cytokine interleukin-1 beta, or IL-1 beta.
AV-299 is a humanized antibody to hepatocyte growth factor (HGF).
AVEO Pharmaceuticals has received a $5 million milestone payment from Biogen Idec International GmbH, a subsidiary of Biogen Idec, for the selection of the first humanized antibody development candidate from its ErbB3 program.
Cheshire, CT) jointly announced that the companies have entered into a definitive license agreement and settlement agreement that resolve the legal disputes between them relating to Alexion's humanized antibody, Soliris (eculizumab) and PDL's patents known as the Queen et al.
However, even if an appropriate vaccine for induction of a desired broadly protective antibody response cannot be developed, through this research, humanized antibody reagents may be generated that can be used to treat life-threatening human infections.
A second Crohn's disease study of certolizumab (Cimzia), a pegylated form of a humanized antibody fragment, is in progress, and patients from both studies will continue to receive the drug for 2 years to gather further safety information.
Zenapax is a humanized antibody created by PDL and developed and marketed by Hoffmann-La Roche, Inc.