human papillomavirus

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any member of a genus of viruses that cause papillomas in humans and various other animals.
human papillomavirus any of numerous species that cause warts, particularly plantar and venereal warts, on the skin and mucous membranes in humans, transmitted by either direct or indirect contact. They have also been associated with cervical cancer.

hu·man pap·il·lo·ma·vi·rus (HPV),

an icosahedral DNA virus, 55 nm in diameter, of the genus Papillomavirus, family Papovaviridae; certain types cause cutaneous and genital warts; other types are associated with severe cervical intraepithelial neoplasia and anogenital and laryngeal carcinomas. Over 70 types have been characterized on the basis of DNA relatedness.

HPV infection is the most common viral sexually transmitted disease. A single unprotected contact with an infected person carries a 60% risk of infection. The interval between exposure and clinical evidence of disease ranges from 3 weeks to 8 months. The annual incidence of genital HPV infection in the U.S. is estimated to be 3.5 million cases, with a prevalence of current infection of 20 million. More than one half of all sexually active women have been infected with one or more genital HPV types. About 15% have DNA evidence of current infection and 1% have genital warts. Most HPV infections are subclinical and transitory, the median duration of infection being about 8 months, with persistence rates of 30% at 1 year and 9% at 2 years. However, some types of HPV can induce genetic mutations in cervical epithelium that can culminate, after a latent period of 10-20 years, in the development of cancer. Carcinoma of the cervix is the most common malignancy in women under age 50. In the U.S., the incidence of cervical cancer is 8.3/100,000, with approximately 14,000 cases and 1,000 deaths annually. As many as 98% of all cancers of the cervix (most of which are squamous cell carcinomas) are believed to be induced by infection with HPV types 16, 18, 31, 33, and a few others. HPV typing in women with atypical squamous cells of undertermined significance (ASC-US) on cervical Papanicolaou smear helps to identify those in whom more intensive surveillance for premalignant change is warranted. Women with external genital warts (condylomata acuminata, which are usually due to HPV type 6 or 11) are not at increased risk of cervical cancer and do not need special surveillance if routine Papanicolaou smears are negative. Some 40% of HIV-positive women develop severe cervical dysplasia caused by HPV, which in many cases proceeds to fatal cancer with an aggressiveness not commonly seen among non-HIV-positive women. Diagnosis of HPV infection is based on visual inspection (including colposcopy with application of acetic acid to the cervix), Papanicolaou smear, and biopsy, with detection of viral DNA in tissue. Treatment options depend on the site and extent of involvement and include surgical excision, cryotherapy with liquid nitrogen, topical application of bichloracetic acid or trichloracetic acid, laser ablation, loop electrosurgical excision, and intralesional injection of interferon. External genital warts usually respond to topical treatment with podofilox gel or imiquimod (a cytokine-inducing agent that can be applied by the patient). Subclinical HPV infection, detectable only by Papanicolaou smear or other laboratory methods, may prove impossible to eradicate. The virus cannot be cultured, and there is no test to confirm cure. In limited trials, a vaccine has demonstrated efficacy in preventing both HPV-16 infection and HPV-related cervical intraepithelial neoplasia in women not previously exposed to the virus.

human papillomavirus

n. Abbr. HPV
Any of various genera of papillomaviruses that cause cutaneous and genital warts in humans, with some strains associated with cervical, anogenital, or laryngeal carcinomas.

human papillomavirus (HPV)

a virus that is the cause of common warts of the hands and feet, as well as lesions of the mucous membranes of the oral, anal, and genital cavities. More than 50 types of HPV have been identified, some of which are associated with cancerous and precancerous conditions. The virus can be transmitted through sexual contact, and specific types of the virus are a precursor to cancer of the cervix. Transmission has taken place without the presence of warts, indicating that it may occur through body fluids, such as semen or cervical secretions. There is no specific cure for an HPV infection, but the virus often can be controlled by podophyllin or interferon and the warts can be removed by cryosurgery, laser treatment, or conventional surgery. A vaccine is available for young girls and women (9-26 years) that protects against four types of HPV.


A DNA virus that causes warts on acral parts which, in those with multiple sexual partners, may be premalignant, especially in those infected with types 16, 18, 31, 33 or 65 genotypes of HPV  have been described. A genotype is distinct if it has < 50% DNA sequence similarity or “homology” with its closest relative. HPV has been identified by in situ hybridisation in epithelial proliferations that are benign (e.g., condyloma acuminatum), or malignant (e.g., squamous cell carcinoma of the penis, anus, and uterine cervix) or of uncertain clinical behaviour (e.g., inverted papillomas of the nasopharynx).

human papillomavirus

See HPV.

hu·man pa·pil·lo·ma·vi·rus

(HPV) (hyū'măn pap'i-lō'mă-vī'rŭs)
DNA virus of the genus Papillomavirus; certain types cause cutaneous and genital warts in humans, including verruca vulgaris and condyloma acuminatum; other types are associated with severe cervical intraepithelial neoplasia and anogenital and laryngeal carcinomas. Over 70 types have been characterized on the basis of DNA relatedness.
Synonym(s): infectious papillomavirus.

human papillomavirus (HPV)

A member of the Papoviridae family that replicate in the nucleus of the host cell. HPV is the cause of common warts (HPV types 2, 4), flat warts (10), genital warts (6, 11), cervical intraepithelial neoplasia (6, 11, 16, 18, 31, 40, 42, 44), cervical cancer (mainly 16, 18), penile cancer and laryngeal cancer (mainly 16). The highest-risk HPV types are believed to be 16, 58, 31, 18, 56, 35, 33, 45, 52,39, 51 and 59.

Human papillomavirus (HPV)

A large family of viruses, some of which cause genital warts; HPV can be transmitted to a fetus during birth.

human papillomavirus (hyōōˈ·mn paˈ·p·lōˈ·m·vīˑ·rs),

n any of the group of papovaviruses that are sexually transmitted and associated with oral or genital carcinomas.

Patient discussion about human papillomavirus

Q. hpv Can i get pregnant

A. You can get pregnant you just need to tell your doctor whats going on so he can keep an eye on the issue.

Q. Should I Vaccinate My Daughter Against HPV? I have a 12 year old daughter. Her School wants all the girls aged 12 and up to be vaccinated against HPV. A lot of Parents are against this vaccine. I want to know more about this vaccine and if I should vaccinate my daughter.

A. before you would like to go on with any vaccination, you should check out this very long list of links:

at the bottom you will also find links in english. vaccinations in general are very disputable/dubious and it is probably time that we learn about it.

Q. Is there a natural cure for hpv?

More discussions about human papillomavirus
References in periodicals archive ?
Putative permissive factors fir human papillomaviruses infection and disease development.
Human papillomaviruses and the genital tract: Old virus, new developments.
Human papillomaviruses in 91 oral cancers from Indian betel quid chewers--high prevalence and multiplicity of infections.
Identification of human papillomaviruses in tumors of the oral cavity in an Indian community.
Lack of evidence for a role of human papillomaviruses in transitional cell carcinoma of the bladder.
Mechanisms used by human papillomaviruses to escape the host immune response.
The last 30 years have seen the discovery of many different types of human papillomaviruses (HPVs) as well as the demonstration of their role in human cancer and their significance as targets for diagnosis and therapy (1).
Human papillomaviruses encode at least six nonstructural proteins: El, E2, E4, E5, E6, and E7.
The E7 proteins of low-and high-risk human papillomaviruses share the ability to target the pRB family member p 130 for degradation.

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