human artificial chromosome

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human artificial chromosome

n.
A large DNA sequence constructed in the laboratory to function like a human chromosome.
References in periodicals archive ?
Stem cell-mediated transfer of a human artificial chromosome ameliorates muscular dystrophy.
Integration-free iPS cells engineered using human artificial chromosome vectors.
Kouprina said that conventional gene therapy uses vectors like viruses to insert genes into chromosomes, which can cause problems which do not happen with human artificial chromosomes because they do not interfere with other parts of the genome.
Researchers were able to create a human artificial chromosome in the lab from chemical building blocks, the Independent reported.
Following a similarly adventuresome strategy, geneticists have now thrown several forms of DNA into human cells and created a long-desired prize: the first human artificial chromosome. "We put in three types of DNA and [the chromosome] self-assembled," says Huntington F.
The human artificial chromosome survived for as long as 6 months in cells, retaining its integrity while replicating during many cell divisions, Willard and his team report in the April Nature Genetics.

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