human leukocyte antigens


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Related to human leukocyte antigens: HLA system, Hla antigens

hu·man leuko·cyte an·ti·gens (HLA),

[MIM*142560]
system designation for the major histocompatibility complex gene products of at least four linked loci (A, B, C, and D) and a number of subloci on the sixth human chromosome that have been shown to have a strong influence on human allotransplantation, transfusions in refractory patients, immune responsiveness to certain antigens, and certain disease associations; autosomal dominant inheritance. See: major histocompatibility complex.

human leukocyte antigens

See HLA.

hu·man leu·ko·cyte an·ti·gens

(HLA) (hyū'măn lū'kō-sīt an'ti-jen)
Any of several members of a system consisting of the gene products of at least four linked loci (A, B, C, and D) and a number of subloci on the sixth human chromosome that have been shown to have a strong influence on human allotransplantation, transfusions in refractory patients, and certain disease associations; more than 50 alleles are recognized, most of which are at loci HLA-A and HLA-B; autosomal dominant inheritance.
References in periodicals archive ?
Reed, "Alloantibody generation and effector function following sensitization to human leukocyte antigen," Frontiers in Immunology, vol.
Nguyen, "Human leukocyte antigen class I epitopes: update to 103 total epitopes, including the C locus," Transplantation, vol.
Shankarkumar, "The human leukocyte antigen (HLA) system," International Journal of Human Genetics, vol.
Among the genetic predisposing factors, human leukocyte antigen (HLA) genes have been reported to be associated with NPC.
Nasopharyngeal carcinoma (NPC) is a malignant epithelial disease, characterized by its distinctive racial and geographic distribution.[sup][1] It is rare in most parts of the world, but endemic in Southern China with an incidence rate of 20/100,000.[sup][2],[3] The major etiological factors include genetic susceptibility, environment factors, and Epstein-Barr virus (EBV) infection.[sup][4] Among all genetic factors, human leukocyte antigen ( HLA ) genes have been shown to have a strong and consistent association with NPC risk.[sup][5] HLA polymorphism can alter disease susceptibility and progression in some tumors.
Associations between human leukocyte antigen type and nasopharyngeal carcinoma in Caucasians in the United States.
Mycobacterium tuberculosis/HIV-1 coinfection and disease: role of human leukocyte antigen variation.
At the core of the mismatch problem are human leukocyte antigens, cell-surface proteins that help direct immune system functions.
Current BMT tissue matching uses serologic tests that compare donor and recipient human leukocyte antigens (HLA), a group of five proteins found on the surfaces of cells.
In the case of kidney transplants, she says, a donor ideally should have two sets of three "human leukocyte antigens," or HLAs--one set inherited from each parent--that match those of the recipient.
The problem is that only about 60% will have an ideal donor, in which all six markers, known as human leukocyte antigens (HLA), match.
Alzheimer researchers are finding increasing evidence of immune components in the brain, including T cells, natural killer cells and human leukocyte antigens. They say this suggests that the blood-brain barrier may not be as impermeable as scientists have assumed, or that the central nervous system may even have its own independent immune arsenal.

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