Hughes' syndrome

Hughes' syndrome

An autoimmune condition caused by an antibody to phospholipid, a major constituent of cell plasma membranes, or an antibody to cardiolipin. It features recurrent thromboses causing strokes, heart attacks and other arterial obstruction effects, or recurrent fetal loss during pregnancy. Other features include renal artery stenosis, avascular necrosis of bone, heart valve disease, metatarsal fractures and systemic lupus erythematosus or a lupus-like disease. Antiphospholipid antibodies are believed to accelerate atheroma by interacting with low-density lipoproteins (LDLs). They can also occur as drug reactions or in certain infectious diseases. There is commonly an abnormally low level of blood platelets (thrombocytopenia). Also known as the antiphospholipid syndrome. (Graham Hughes, who described the syndrome in 1983).
References in periodicals archive ?
Naomi, 36, who has been married for nine years to businessman,Oliver, suffers from Hughes' Syndrome, which occurs when blood is too thick to pass through the narrowest blood vessels to feed a growing foetus.
But last year, her life was changed when she saw a patient with the same problems being diagnosed with the blood disorder Hughes' syndrome on the TV show City Hospital.
One form, known as Hughes' Syndrome, is responsible for 20 per cent of all miscarriages.