Hughes' syndrome

Hughes' syndrome

An autoimmune condition caused by an antibody to phospholipid, a major constituent of cell plasma membranes, or an antibody to cardiolipin. It features recurrent thromboses causing strokes, heart attacks and other arterial obstruction effects, or recurrent fetal loss during pregnancy. Other features include renal artery stenosis, avascular necrosis of bone, heart valve disease, metatarsal fractures and systemic lupus erythematosus or a lupus-like disease. Antiphospholipid antibodies are believed to accelerate atheroma by interacting with low-density lipoproteins (LDLs). They can also occur as drug reactions or in certain infectious diseases. There is commonly an abnormally low level of blood platelets (thrombocytopenia). Also known as the antiphospholipid syndrome. (Graham Hughes, who described the syndrome in 1983).
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
References in periodicals archive ?
MI in children with angiographically "normal" coronary arteries could occur because of hypercoagulable states--nephrotic syndrome and antiphospholipid syndrome (Hughes' syndrome), [3-6] coronary artery spasm, [7-8] coronary embolization [9] and myocardial bridging.
Naomi, 36, who has been married for nine years to businessman,Oliver, suffers from Hughes' Syndrome, which occurs when blood is too thick to pass through the narrowest blood vessels to feed a growing foetus.
Tickets are pounds 100 each, with pounds 2 from each donated to the Hughes' Syndrome Foundation.