HSPA8

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HSPA8

A gene on chromosome 11q24.1 that encodes a ubiquitous member of the heat shock protein 70 (HSP70) family which acts as a chaperone by binding to nascent polypeptides to facilitate correct folding. HSPA8 also acts as an ATPase in disassembling clathrin-coated vesicles during transport of membrane components through the cell. It also downregulates transcription of CITED and HSC70.
References in periodicals archive ?
The cytosolic/ nuclear HSC70 and HSP90 molecular chaperones are important for stomatal closure and modulate abscisic acid-dependent physiological responses in Arabidopsis.
Moreover, aberrant UCHL1 is able to interact with Lamp2a, Hsc70, and Hsp90 thus inhibiting chaperone mediated autophagy- (CMA-) dependent degradation and causing the accumulation of CMA substrates (e.
The HSP70 family is encoded by 2 different genes, constitutive type HSC70 (heat shock cognate 70) and inducible type HSP70 (Boutet et al.
Comprehensive review on the HSC70 functions, interactions with related molecules and involvement in clinical diseases and therapeutic potential.
Adaptive divergence in a high gene flow environment: Hsc70 variation in the European flounder (Platichthys flesus).
It interacts via coiled-coil motifs with several proteins, including BiP/Grp78 and Hsc70, two members of the heat-shock-70 (Hsp70) family of proteins.
Exercise-induced increase in ROS levels triggers an adaptive antioxidant response that is mediated via mitogen activated protein kinases (MAPK p38, ERK 1, and ERK 2) [323, 327-329], cAMP-response-element binding (CREB) [330, 331], and synapsin [330, 331], to activate redox-sensitive transcription factors such as NF-[kappa]B [323, 332, 333] and AP-1 [327, 333], resulting in increased expression of antioxidant enzymes [334] such as superoxide dismutase (SOD) [323,333] and catalase [333], repair proteins such as hear shock proteins HSP25, HSP60, HSP72, HSP70, and heat shock cognate 70 HSC70 [315, 333-336], proteasomes complex, and nitric oxide synthase (NOS) [308, 323].