Without sufficient hormone-sensitive lipase activity, obese people may have more trouble getting access to the energy stored in their fat cells, possibly making it more difficult to lose weight.
A blend from Mediterranean citrus fruit and a South American seed has been shown to increase hormone-sensitive lipase activity in white adipose tissue cells, restoring their ability to free up--and burn off--their stores of excess energy.
Targeted disruption of hormone-sensitive lipase
results in male sterility and adipocyte hypertrophy, but not in obesity.
Adipose triglyceride lipase and hormone-sensitive lipase
protein expression is decreased in the obese insulin-resistant state.
Long-term regulation of lipolysis and hormone-sensitive lipase by insulin and glucose.
Hormone-sensitive lipase from adipose tissue of rat.
Effect of dietary saturated fatty acids on intracellular free fatty acids and kinetic properties of hormone-sensitive lipase
of rat adipocytes.
PKA then phosphorylates two proteins, hormone-sensitive lipase
(HSL) and perilipin, in adipocytes and causes translocation of HSL from the cytosol to the lipid droplet surface, a crucial step for the lipase access to its triacylglycerol substrates (Sztalryd et al.
Aerobic exercise improves the ability to mobilize and break apart triglycerides for energy use, whereas obesity makes the fat-breakdown enzyme hormone-sensitive lipase
less sensitive to epinephrine.
Based on the gene expression profile, up-regulation of hormone-sensitive lipase
and enhancement of the lipolytic activity by the treatment of adipocytes with cyanidin 3-glucoside, have been demonstrated.
Translocation of hormone-sensitive lipase
and perilipin upon lipolytic stimulation of rat adipocytes.
Lipoprotein and hormone-sensitive lipases
in porcine adipose tissue.