This then leads to increased production of a fat-burning enzyme called hormone sensitive lipase
, and releases stored triglycerides (fats) from the fat cells.
The effect of tolbutamide on lipoproteins and lipoproteinlipase and hormone sensitive lipase
The increased activity of hormone sensitive lipase
causes increased release of free fatty acids and glycerol from adipocytes.
Fatty acid synthase, hormone sensitive lipase
, lipoprotein lipase, adipose triacylglycerol lipase, acyl-CoA, diacylglycerol acyltransferase 2, elongase of very long-chain fatty acid 6, and [DELTA]5 and [DELTA]6 fatty acid desaturase activity was detected and showed a negative trend with an increase of salinity, and no significant differences were found among salinity groups (P > 0.
In Tribolium castaneum, there are 54 genes for lipase enzyme out of which 25 are for neutral lipases, 25 are for acidic lipases, no gene for lipase type 2, 1 gene for lipase type 3, 2 genes for GDSL and 1 gene for hormone sensitive lipase
which shows that neutral and acidic lipases, predominate in red flour beetle (Horne et al.
In addition, enhancement of insulin secretion also inhibits hormone sensitive lipase
and increases the utilization of glucose and thereby decreasing the mobilization of FFAs from the fat depots.
2) Also, the higher concentration of insulin in HHS as compared to DKA, may be sufficient to inhibit the action of hormone sensitive lipase
, thus thwarting triglyceride breakdown to ketones in adipose tissue.
The increased lipolysis was accompanied by an increase in the expression of hormone sensitive lipase
The main steps of this cascade involve: activation of adenylate cyclase by [beta]-adrenergic receptors, rise in cAMP and activation of protein kinase A (PKA) resulting in the stimulation of lipolysis by hormone sensitive lipase