hormone-sensitive lipase

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hormone-sensitive lipase

an enzyme that catalyzes the release of fatty acids from adipose tissues.

hormone-sensitive lipase

enzyme responsible for hydrolysis of triglyceride molecules and therefore release of free fatty acids and glycerol. It functions mainly in adipose tissue and muscle. Activity of the enzyme in both sites is increased during endurance-type exercise, providing free fatty acids for resynthesis of ATP.
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This then leads to increased production of a fat-burning enzyme called hormone sensitive lipase, and releases stored triglycerides (fats) from the fat cells.
The increased activity of hormone sensitive lipase causes increased release of free fatty acids and glycerol from adipocytes.
Fatty acid synthase, hormone sensitive lipase, lipoprotein lipase, adipose triacylglycerol lipase, acyl-CoA, diacylglycerol acyltransferase 2, elongase of very long-chain fatty acid 6, and [DELTA]5 and [DELTA]6 fatty acid desaturase activity was detected and showed a negative trend with an increase of salinity, and no significant differences were found among salinity groups (P > 0.
In Tribolium castaneum, there are 54 genes for lipase enzyme out of which 25 are for neutral lipases, 25 are for acidic lipases, no gene for lipase type 2, 1 gene for lipase type 3, 2 genes for GDSL and 1 gene for hormone sensitive lipase which shows that neutral and acidic lipases, predominate in red flour beetle (Horne et al.
In addition, enhancement of insulin secretion also inhibits hormone sensitive lipase and increases the utilization of glucose and thereby decreasing the mobilization of FFAs from the fat depots.
2) Also, the higher concentration of insulin in HHS as compared to DKA, may be sufficient to inhibit the action of hormone sensitive lipase, thus thwarting triglyceride breakdown to ketones in adipose tissue.
The increased lipolysis was accompanied by an increase in the expression of hormone sensitive lipase (1.
The main steps of this cascade involve: activation of adenylate cyclase by [beta]-adrenergic receptors, rise in cAMP and activation of protein kinase A (PKA) resulting in the stimulation of lipolysis by hormone sensitive lipase (HSL).

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