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Statistician Richard Peto, director of the Cancer Studies Unit at England's Oxford University, and an internatinal team of collaborators culled data from 133 randomized breast cancer trials involving a total of 75,000 women worldwide who had received a variety of postsurgical treatments, including hormonal therapy and chemotherapy.
Previous research has suggested that "hormonal therapy, when added to radiation therapy (RT) for treating unfavorable-risk prostate cancer, leads to an increase in survival except possibly in men with moderate to severe comorbidity [co-existing illnesses].
Based on a physical examination, a patient's medical history and the success or failure of previously prescribed acne treatments, dermatologists may recommend hormonal therapy to enhance the results of acne treatment in women.
All of the patients received hormonal therapy or chemotherapy within 3 months of diagnosis.
Breast surgeon Gordon Wishart of Addenbrooke's Hospital, Cambridge, said: "This means a number of patients are denied the benefits of hormonal therapy after surgery."
GlaxoSmithKline (NYSE:GSK) reported on Friday the grant of accelerated approval from the US Food and Drug Administration (FDA) for a new combination regimen using TYKERB (lapatinib) as a first-line, all-oral treatment for women with metastatic breast cancer.TYKERB is now indicated in combination with letrozole for the treatment of postmenopausal women with hormone receptor positive metastatic breast cancer that overexpresses the HER2 receptor, for whom hormonal therapy is indicated, according to the company.
An update to the WHI findings will be coming soon, tracking 4 more years of follow-up in women after they had ceased taking combination hormonal therapy, said Dr.
WASHINGTON -- Response to hormonal therapy does not accurately predict whether a patient has endometriosis, Dr.
Some chapters are broader in scope, discussing such topics as clinical strategies for cancer treatment, preclinical aspects of cancer drug discovery, pharmacokinetics, infertility after cancer chemotherapy, carcinogenesis of anticancer drugs, antibody therapies of cancer, hematopoietic growth factors, the role of the Food and Drug Administration in oncology product development, and hormonal therapy for breast cancer.
"We know from prior studies that only those tumors that express hormone receptors--ER being the most predictive--respond to hormonal therapy," Dr.
About 50% of patients get no treatment, while 25% undergo salvage radiation, and another 25% receive hormonal therapy.
In this group, the panel also noted one randomized, controlled trial that found prolonged survival among men who received neoadjuvent and current hormonal therapy with conventional-dose external beam radiation therapy versus radiation alone.