homovanillic acid

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ho·mo·va·nil·lic ac·id (HVA),

(hō'mō-vă-nil'ik as'id),
4-Hydroxy-3-methoxyphenylacetic acid; a phenol found in human urine; produced through the methylation of homoprotocatechuic acid on the meta-OH group. It is the principal urinary metabolite of dopa and dopamine.

homovanillic acid

HVA Physiology A major dopamine metabolite used to synthesize epinephrine and norepinephrine and excreted in urine; HVA is usually measured with the major catecholamines and other catecholamine metabolites; HVA is ↑ in neuroblastoma and ganglioneuroma Ref range 0-15 mg/24 hr urine. See Hypertension, Pheochromocytoma.

ho·mo·va·nil·lic ac·id

(HVA) (hō'mō-vă-nil'ik as'id)
A phenol found in human urine; produced through the methylation of homoprotocatechuic acid on the meta-OH group.

ho·mo·va·nil·lic ac·id

(HVA) (hō'mō-vă-nil'ik as'id)
A phenol found in human urine.
References in periodicals archive ?
Measurement of urinary vanilmandelic acid and homovanillic acids by high-performance liquid chromatography with electrochemical detection following extraction by ion-exchange and ion-moderated partition.
[4] Nonstandard abbreviations: TH, tyrosine hydroxylase; L-dopa, L-dihydroxyphenylalanine; B[H.sub.4], tetrahydrobiopterin; THD, tyrosine hydroxylase deficiency; CSF, cerebrospinal fluid; 5-HIAA, 5-hydroxyindoleacetic acid; HVA, homovanillic acid; MHPG, 3-methoxy-4-hydroxy-phenylglycol; and VMA, vanillylmandelic acid.
Homovanillic acid (HVA) level in CSF was mildly elevated, at 80.9ng/ml (normal, <50ng/ml).
Chronic manganese overload stimulates monoamine oxidase activity, increasing dopaminergic degradation and accumulation of its metabolite, homovanillic acid.
These antidepressant-like effects were associated with higher concentrations of norepinephrine and dopamine and their metabolites 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA), respectively, in the hippocampus.
Homovanillic acid and 5-hydroxyindoleacetic acid cerebrospinal fluid levels: a study with and without probenecid administration of their relationship to the state of consciousness after head injury.
In this study, significant correlations were found between the phenylalanine (Phe) to tyrosine (Tyr) ratio and CSF concentrations of both dopamine and its metabolite, homovanillic acid (62).
dioica methanolic leaf extract showed the presence of cinnamic acid, coumarins, and homovanillic acid as phenolic compounds.
Four compounds (both caffeic acid hexosides (m/z 341), homovanillic acid hexoside (m/z 343), and first dicaffeoylquinic acid isomer (m/z 515)) showed increasing trends, three compounds showed decreasing trends, and eight compounds had maximum levels at half-ripe stage.
This change was associated with increased levels of DA metabolites: homovanillic acid in the prefrontal cortex and in the hippocampus, as well as 3,4-dihydroxyphenylacetic acid (DOPAC) in the prefrontal cortex [103].
The neuroprotective assessment of echinacoside (9) showed that it prevents the 6-hydroxydopamine- (6-OHDA-) induced extracellular loss of monoamine neurotransmitters, such as 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid in rat striatum [113].