homotypic


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Related to homotypic: heterotypic

ho·mo·typ·ic

, homotypical (hō'mō-tip'ik, i-kăl),
Of the same type or form; corresponding to the other one of two paired organs or parts.
Farlex Partner Medical Dictionary © Farlex 2012

homotypic

adjective Referring to interactions between similar structures. For proteins, homotypic refers to binding of one protein of another of a similar kind, as would be the formation of a homodimer. For cells, homotypic refers to the binding of a cell to one or more similar cells.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

ho·mo·typ·ic

, homotypical (hō'mō-tip'ik, -i-kăl)
Of the same type or form; corresponding to the other one of two paired organs or parts.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
References in periodicals archive ?
For transplantation, in order to ensure that the number of transplanted beta cells were identical, one-well homotypic PIs or two-well heterotypic PIs were injected subcutaneously into the back of nude mice.
Furthermore, these LC domains from different RNA-binding proteins can coassemble with each other to form either homotypic or heterotypic oligomers, although the affinities between different LC domains may differ [35].
Ronchi et al., "Impaired SLAM-SLAM homotypic interaction between invariant NKT cells and dendritic cells affects differentiation of IL-4/IL-10-secreting NKT2 cells in nonobese diabetic mice," The Journal of Immunology, vol.
NOD1 activation resulting from LRR sensing of NOD1 ligand is initiated by a NOD1 conformational change that allows a homotypic interaction between NOD1 CARD domains and NOD1 auto-oligomerization; this, in turn, is followed by recruitment of RIP2, its initial down-stream signaling molecule.
In the presence of [Ca.sup.2+], extracellular portions of desmogleins and desmocollins bind adjacent identical molecules of neighboring cells (homotypic binding), forming a "cadherin zipper", identified in X-ray crystallographic studies.
For biological functions, like angiogenic process, both homotypic and heterotypic cellular interactions are needed.
Moreover, T[beta]RIII controlled MM cell adhesion, augmenting homotypic MM cell adhesion while reducing MM heterotropic adhesion to BM stromal cells [235].
Recent studies have indicated that nephrin homotypic interactions influence cytoplasmic posttranslational modifications and signaling [3, 7, 8].
Several homotypic cell sheets may be layered on top of each other to reconstruct homogenous 3D tissues such as myocardium [18].
The adherens junction is a principal component of intercellular adhesion and is comprised of transmembrane cadherins forming homotypic interactions between adjacent cells and cytoplasmic catenins linking the cadherins to the cytoskeleton.