For transplantation, in order to ensure that the number of transplanted beta cells were identical, one-well homotypic
PIs or two-well heterotypic PIs were injected subcutaneously into the back of nude mice.
Furthermore, these LC domains from different RNA-binding proteins can coassemble with each other to form either homotypic
or heterotypic oligomers, although the affinities between different LC domains may differ .
Ronchi et al., "Impaired SLAM-SLAM homotypic
interaction between invariant NKT cells and dendritic cells affects differentiation of IL-4/IL-10-secreting NKT2 cells in nonobese diabetic mice," The Journal of Immunology, vol.
NOD1 activation resulting from LRR sensing of NOD1 ligand is initiated by a NOD1 conformational change that allows a homotypic
interaction between NOD1 CARD domains and NOD1 auto-oligomerization; this, in turn, is followed by recruitment of RIP2, its initial down-stream signaling molecule.
32b), because both are based on homotypic
In the presence of [Ca.sup.2+], extracellular portions of desmogleins and desmocollins bind adjacent identical molecules of neighboring cells (homotypic
binding), forming a "cadherin zipper", identified in X-ray crystallographic studies.
For biological functions, like angiogenic process, both homotypic
and heterotypic cellular interactions are needed.
Moreover, T[beta]RIII controlled MM cell adhesion, augmenting homotypic
MM cell adhesion while reducing MM heterotropic adhesion to BM stromal cells .
Recent studies have indicated that nephrin homotypic
interactions influence cytoplasmic posttranslational modifications and signaling [3, 7, 8].
cell sheets may be layered on top of each other to reconstruct homogenous 3D tissues such as myocardium .
The adherens junction is a principal component of intercellular adhesion and is comprised of transmembrane cadherins forming homotypic
interactions between adjacent cells and cytoplasmic catenins linking the cadherins to the cytoskeleton.