(hō'mō-trō'pik), Do not confuse this word with homotopic.
Referring to the binding of the same ligand to a macromolecule; for example, the binding of four O2 to hemoglobin is homotropic cooperativity.
Farlex Partner Medical Dictionary © Farlex 2012
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(a) The kind of ligand that binds to the oligomer: (i) "homotropic effect", as a result of binding of similar ligands (substrate); (ii) "non-cooperative heterotropic effect", as a result of the interaction (binding) between different ligands, substrate and activator; and (iii) "cooperative heterotropic effect", as the result of the interaction (binding) of different ligands, substrate and inhibitor.
According to POM observations, T12-CN displays a smectic-A phase of low order having a strong tendency to form a homotropic texture upon cooling from its isotropic state.
In a homotropic grafting experiment in which quail PE cells were grafted to chicken hearts it has been found that some Prox-1-positive lymphatic trunks (along the great arteries) contain QH1-positive endothelial cells (derived from quail).
Miller, "Homotropic allosteric regulation in monomeric mammalian glucokinase," Archives of Biochemistry and Biophysics, vol.
A case of homotropic regulation of substrate binding.
spiculifer hemoglobin thus does not show any homotropic or heterotropic interactions and behaves like a myoglobin.
On the other hand, Pip's pugilistics with Herbert, Drummle, and Orlick (as well as Magwitch's with Compeyson) represent a form of contact too close for comfort: however ecstatically and erotically charged one may suspect these passages of being, the form they take -- of increasingly savage violence -- must sit uneasily with any gleefully homotropic reading.