AHLs are highly conserved molecules having the common homoserine lactone
moiety but differ in the length and structure of the acyl side chain (3).
e peptide molecules which were produced by Gram positive bacteria and acyl homoserine lactone
(AHL) which were produced by Gram negative bacteria .
The Pseudomonas autoinducer N-(3-oxododecanoyl) homoserine lactone
induces cyclo-oxygenase-2 and prostaglandin E2 production in human lung fibroblasts: Implications for inflammation.
To date, the best known communication between bacteria occurs via the N-acyl homoserine lactone
(AHL): The enzyme Luxl produces signals that are recognised by the LuxR receptor, at which point the bacteria develop certain properties and modulate their behaviour towards one another.
AHLs contain a common homoserine lactone
ring, differing in their carbon lenght (4 to 18 carbons), degree of saturation, and the presence of C3 acyl chain modifications.
In Gram negative bacteria, the QS mediated pathogenesis occurs through N-acyl homoserine lactone
(AHL) signal dependent mechanism (Smith and Iglewski 2003).
stewartii uses 3oxohexanoyl acyl carrier protein and SAdenosylL Methionine (SAM) as substrates to make 3oxohexanoyl homoserine lactone
Plants secrete substances that mimic bacterial N-acyl homoserine lactone
signal activities and affect population density-dependent behaviors in associated bacteria.
aeruginosa autoinducer 3O-C12 homoserine lactone
provokes hyperinflammatory responses from cystic fibrosis airway epithelial cells.
For example, red algae secrete halogenated furanones and enones that act as antagonists of acylated homoserine lactone
signaling molecules present in biofilms.
aeruginosa it appears that an acylated homoserine lactone
(acyl-HSL) is an important player in this type of cell to cell signaling .
A receptor protein from the LuxR family of transcriptional regulators, upon binding an acylated homoserine lactone
compound, interacts with the lux box, modulating the activity of the promoter.