homogentisate 1,2-dioxygenase

(redirected from Homogentisic acid oxidase)
Also found in: Acronyms.

ho·mo·gen·tis·ate 1,2-di·ox·y·gen·ase

(hō'mō-jen'tis-āt dī-oks'i-jen-ās),
An iron-containing enzyme that catalyzes the oxidative cleavage of the benzene ring in homogentisic acid by O2, forming 4-maleylacetoacetate; an absence or deficiency of this enzyme will result in alcaptonuria.
Farlex Partner Medical Dictionary © Farlex 2012
References in periodicals archive ?
Sbou' explained that Alkaptonuria is caused by deficiency of the enzyme homogentisic acid oxidase (HGO), as a consequence of the enzymatic block, the homogentisic acid (HGA) accumulates in body tissues, vertebrae, joints and heart valves,.
Ochronosis results from a deficiency of homogentisic acid oxidase and leads to deposition of homogentisic acid in tissues.