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ho·mo·gen·tis·ate 1,2-di·ox·y·gen·ase(hō'mō-jen'tis-āt dī-oks'i-jen-ās),
An iron-containing enzyme that catalyzes the oxidative cleavage of the benzene ring in homogentisic acid by O2, forming 4-maleylacetoacetate; an absence or deficiency of this enzyme will result in alcaptonuria.
Synonym(s): homogentisic acid oxidase
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