homodimer


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Related to homodimer: Heterodimer

homodimer

(hō-mō-dī'mĕr),
A molecule composed of paired identical proteins.
[homo- + dimer]
References in periodicals archive ?
Huang et al., "Sulfasalazine treatment suppresses the formation of HLA-B27 heavy chain homodimer in patients with ankylosing spondylitis," International Journal of Molecular Sciences, vol.
For this study, in order to estimate the feasibility of scaffold QS/FGS, the essay "Live/Dead" with homodimer calceina- ethidium was used, in which the medium was removed to evaluate and saline phosphate (PBS) was added; the cell sample was washed to remove or dilute any residue supplemented, the PBS was removed with care not to dislodge the cells, 0.25 mL of 0.5 mL of calcein and ethidium homodimer was added to Hanks to cover the cell culture.
A and B chains of 3-phytase B initially form a homodimer (Figure 3) (PDB ID: 1QFX) and its 2D structure corresponds to 38% alpha helices, 12% beta sheets, and 50% random coils.
The VEGF is a homodimer that comprises 2 polypeptide chains and has a molecular mass of approximately 45 kDa; the single stranded form has a molecular weight of about 23 kDa under denaturing conditions.
In the absence of JH, Met is present as an inactive homodimer. Upon JH binding to the PAS-B domain, Met undergoes a conformational change that liberates Met from the homodimer complex and allows it to bind Taiman [43,45-47].
HexA is a heterodimer of subunits [alpha] (encoded by the gene HexA) and (encoded by the gene HexB), whereas HexB is a homodimer of subunits.
Additionally biochemical studies suggest that transitory interaction between two N-terminal domains of the HSP90 homodimer occurs in an ATP dependent manner, and this provides the mechanistic basis for the ATPase driven molecular clamp.
Association of all three types of Fc gamma R (CD64, CD32, and CD16) with a gamma-chain homodimer in cultured human monocytes.
The viability of adult primary RPE cell sheet grafts after storage has previously been investigated by Tezel and coworkers using a calcein and ethidium homodimer viability kit [33].
The UVRAG CCD heterodimerizes with the Beclin 1 CCD, disrupting the Beclin 1 CCD homodimer and increasing autophagy levels in the cell.
Pal3 was originally discovered in random site selection assay with in vitro translated proteins and was featured by its ability to bind PPARgamma not only as heterodimer with RXRalpha but also as a homodimer [19].
Binding of a single erythropoietin molecule to a receptor homodimer (Jelkmann et al., 2008) causes a conformational change of the receptor, thus activating the receptor and triggering the downstream, intracellular erythropoiesis signaling cascade (described in more detail below) that results in proliferation, differentiation, and maturation of RBCs (see Figure 4) (Brines, 2010; Bunn, 2007; Byts & Siren, 2009; Koury et al., 2002).