human

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Related to Homo sapien: primate, human, Human evolution, Cro magnon

factor IX (human)

AlphaNine SD, Immune VH (CA), Mononine

factor IX (recombinant)

BeneFix

factor IX complex

Bebulin VH, Defix (UK), Hipfix (UK), Octaplex (CA), Profilnine SD, Proplex T (heat-treated), Replenine (UK)

Pharmacologic class: Blood modifier

Therapeutic class: Antihemophilic

Pregnancy risk category C

Action

Converts fibrinogen to fibrin, increasing levels of clotting factors

Availability

Powder for injection: Various strengths; units specified on label

Indications and dosages

Factor IX deficiency (hemophilia B or Christmas disease); anticoagulant overdose

Adults and children: Dosage individualized; drug administered I.V. Use following equations to calculate approximate units needed:

Human product-1 unit/kg times body weight (in kg) times desired increase in factor IX level, expressed as percentage of normal

Recombinant product-1.2 units/kg times body weight (in kg) times desired increase in factor IX level, expressed as percentage of normal

Proplex T-0.5 unit/kg times body weight (in kg) times desired increase in factor IX level, expressed as percentage of normal

Off-label uses

• Hepatic dysfunction

• Esophagitis

• Unspecified GI hemorrhage (human product)

Contraindications

• Hypersensitivity to mouse or hamster protein (with BeneFix)

• Fibrinolysis

Precautions

Use cautiously in:

• recent surgery

• pregnant patients

• children younger than age 6 (safety and efficacy not established).

Administration

Give by slow I.V. infusion. Average infusion rate is 100 units (2 to 3 ml)/minute; don't exceed 10 ml/minute.

• If prescribed, administer hepatitis B vaccine before giving factor IX.

• Know that dosage is highly individualized according to degree of factor IX deficiency, patient's weight, and bleeding severity.

• Don't use glass syringe. Don't shake reconstituted solution or mix with other I.V. solutions.

Adverse reactions

CNS: light-headedness, paresthesia, headache

CV: blood pressure changes, thromboembolic reactions, myocardial infarction (MI)

EENT: allergic rhinitis

GI: nausea, vomiting

Hematologic: disseminated intravascular coagulation (DIC)

Respiratory: pulmonary embolism

Skin: rash, flushing, diaphoresis, pruritus, urticaria

Other: altered taste, fever, chills, burning sensation in jaw and skull, pain at I.V. injection site, hypersensitivity reactions including anaphylaxis

Interactions

Drug-drug. Aminocaproic acid: increased risk of thrombosis

Patient monitoring

• Be aware that factor IX complex may transmit hepatitis.

• Closely monitor vital signs during infusion.

Observe for hemolytic reaction. If it occurs, stop infusion, flush line with saline solution, and notify prescriber immediately.

• Monitor I.V. injection site closely.

Monitor coagulation studies closely. Know that drug may cause thromboembolic disorders, including MI and DIC.

Patient teaching

• Inform patient that drug may transmit diseases.

Tell patient to immediately report signs and symptoms of hypersensitivity reaction, including rash, hives, tightness in chest, wheezing, shortness of breath, and swelling of throat or lips.

Advise patient to immediately report unusual bleeding or bruising.

• Caution patient to avoid activities that can cause injury.

• Tell patient to wear medical identification stating that he has a blood-clotting disorder.

• Instruct patient to notify surgeon or dentist of his blood-clotting disorder before surgery or invasive dental procedures.

• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs mentioned above.

human

(hyo͞o′mən)
n.
A member of the primate genus Homo, especially a member of the species Homo sapiens, distinguished from other apes by a large brain and the capacity for speech.
adj.
Of, relating to, or characteristic of humans: the course of human events; the human race.

hu′man·hood′ n.
hu′man·ness n.

human

[h(y)o̅o̅′mən]
Etymology: L, humanus
a member of the genus Homo and particularly of the species H. sapiens.

human

see homo-.

human carriers
humans who act as active carriers of diseases of animals and infect animals.
human immunodeficiency virus
includes HIV1 (more common) and HIV2 which are lentiviruses that cause acquired immunodeficiency disease (AIDS) in humans.
human leukocyte antigen
see major histocompatibility complex.

Patient discussion about human

Q. I am a man with breast cancer. Hello friends, you might have heard about breast cancer in women but here I am a man with breast cancer. Is Herceptin licensed to treat me?

A. Hi, what were your symptoms and when did you discover you had breast cancer?

Q. what are the basics products we as a humans, need to have in our diet?

A. A regular healthy diet should be comprised of a 40-50% carbohydrate (bread, rice, etc.), 30-40% protein (dairy, meat, chicken, fish) and 20% fat. Other important ingredients are fruit and vegetables, that contain large amounts of fibers and vitamins.

Q. Is there a difference between a man's diet and a woman's diet? let say for the point of it the weight the same and they are in the same age .

A. no one should have the same exact diet, you need to find what works for you and helps you achieve your goals.

the base of the diet could be the same, for example burn calories then you consume. But other wise, find what works for you.

More discussions about human
References in periodicals archive ?
It also means that if, as well as interbreeding with Neanderthals and sharing artistic ideas with them, the first groups of Homo sapiens to enter Europe massacred them and helped make them extinct, it was our fellow thinking beings we were killing.
By contrast, Homo sapiens did have language, as shown by the remarkable cave paintings in Spain and France.
The researchers studied measurements from the fossilized heel bones of 13 ancient Homo sapiens and six Neandertals that lived between 30,000 and 100,000 years ago.
We will do so by briefly addressing the question of contemporaneity between Homo erectus and Homo sapiens in Java, as proposed by recent dates for the site of Ngandong.
Experimental archaeologist Metin Eren, from the University of Exeter, said: "Our research disputes a major pillar holding up the long-held assumption Homo sapiens were more advanced.
The disadvantage would have made it increasingly difficult for Neanderthals to compete with Homo Sapiens as the Ice Age worsened.
Though the Neanderthal might not be an ancestor or subspecies of Homo sapiens, according to researchers at UIC, evolution (defined as a gradual process in which something changes) of the species is proven by the changes in human dentition.
Based on geological evidence and the discovery of human remains, many assumed that Homo sapiens sapiens arrived in America from Asia about 12,000 BP when the Bering land bridge was open in one of its periodical dry land phases.
These infections are caused by multihost parasites for which the reservoir of infection depends on hosts other than Homo sapiens.
They do not contend that Homo sapiens as a whole is endangered or threatened, nor does that species appear to be.
And in Bicentennial Man, Andrew (Robin Williams) is a household robot whose mis-wired circuitry provides him with a "heart" and enables him to grow into a person with more wit, grace, and humanity than most of the Homo sapiens he encounters.
Since horses and cattle were the species of highest utility to Homo sapiens, their absence from an entire hemisphere called into question standard assumptions about divine intent.