Holt-Oram syndrome

Holt-O·ram syn·drome

(hōlt ō'răm), [MIM*142900]

atrial septal defect in association with fingerlike or absent thumb and other deformities of the forearm; autosomal dominant inheritance, caused by mutation in the T-box5 gene (TBX5) on chromosome 12q.

Farlex Partner Medical Dictionary © Farlex 2012

Holt-Oram syndrome

An autosomal dominant condition (OMIM:142900) characterised by atrial septal defect in association with finger-like or absent thumb and other deformities of the forearm.

Molecular pathology
Defects of TBX5, which encodes a DNA-binding transcription factor involved in regulating cardiac development and specification of limb identity, cause Holt-Oram syndrome.

Holt-Oram syndrome

Heart-hand syndrome Molecular cardiology An AD disorder with structural defects of the heart and upper limbs Clinical Upper limb defects may be uni- or bilateral and involve structures of the embryonic radial ray causing aplasia, hypoplasia, fusion and anomalous development of the radial, carpal and thenar bones; defects include triphalangeal or absent thumbs, foreshortened arms and phocomelia; cardiac abnormalities are variably present and are either structural–eg, single or multiple atria, VSD, or functional–eg, bradycardia, various degrees of AV block; other defects in HOS include vertebral, anal, tracheoesophageal, and renal defects

Holt,

Mary, 20th century English cardiologist.

Holt-Oram syndrome - atrial septal defect in association with fingerlike or absent thumb and other deformities of the forearm.

Oram,

Samual, 20th century English cardiologist.

Holt-Oram syndrome - see under Holt, Mary

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References in periodicals archive ?

Holt-Oram syndrome is an autosomal dominant disorder associated with aplasia or hypoplasia of the digital rays and radius with CHD.

The heart-hand syndrome type I, also known as Holt-Oram syndrome is the most common and is usually associated with an atrial septal defect.

This is the first reported case of Holt-Oram syndrome association with tricuspid atresia and atrial septal aneurysm.

Our case had the characteristic skeletal abnormalities of the upper limb, a normal platelet count, no history of skeletal deformity in the family and no history of radiation exposure and thalidomide intake in mother, thereby suggestive of the sporadic type of Holt-Oram syndrome.

Holt-Oram syndrome is known to be associated with a panaroma of cardiac defects.

Variation in severity of cardiac disease in Holt-Oram syndrome. Am J Med Genet.

Holt-Oram syndrome: A rare variant

Holt-Oram syndrome (OMIM-142900) involves absent thumbs along with radial deficiency and cardiac anomalies.12 One form of Holt-Oram syndrome is caused by mutations in TBX5.

Study of non-syndromic thumb aplasia in six independent cases

Preimplantation genetic diagnosis of human congenital heart malformation and Holt-Oram syndrome. American Journal of Medical Genetics Part A, 126(1), 93-98.