Hodgkin disease


Also found in: Dictionary, Thesaurus, Legal, Encyclopedia.

Hodg·kin dis·ease

(hoj'kin),
a disease marked by chronic enlargement of the lymph nodes, often local at the onset and later generalized, together with enlargement of the spleen and often of the liver, no pronounced leukocytosis, and commonly anemia and continuous or remittent (Pel-Ebstein) fever; considered to be a malignant neoplasm of lymphoid cells of uncertain origin (Reed-Sternberg cells), associated with inflammatory infiltration of lymphocytes and eosinophilic leukocytes and fibrosis; can be classified into lymphocytic predominant, nodular sclerosing, mixed cellularity, and lymphocytic depletion types; a similar disease occurs in domestic cats.
Synonym(s): Hodgkin lymphoma, lymphadenoma (2)

Hodg·kin dis·ease

(hoj'kin di-zēz')
A disease marked by chronic enlargement of the lymph nodes, often local at the onset and later generalized, together with enlargement of the spleen and often of the liver, no pronounced leukocytosis, and commonly anemia and continuous or remittent (Pel-Ebstein) fever; considered to be a malignant neoplasm of lymphoid cells of uncertain origin (Reed-Sternberg cells), associated with inflammatory infiltration of lymphocytes and eosinophilic leukocytes and fibrosis; can be classified into lymphocytic predominant, nodular sclerosing, mixed cellularity, and lymphocytic depletion type; a similar disease occurs in domestic cats.

Hodgkin,

Thomas, English physician, 1798-1866.
Hodgkin disease - malignant neoplasm of lymphoid cells of uncertain origin, associated with inflammatory infiltration of lymphocytes and eosinophilic leukocytes and fibrosis. Synonym(s): lymphadenoma
Hodgkin-Key murmur - a musical diastolic murmur.
Hodgkin sarcoma
non-Hodgkin lymphoma - a lymphoma other than Hodgkin disease.

Hodg·kin dis·ease

(hoj'kin di-zēz')
Disease marked by chronic enlargement of the lymph nodes, often local at the onset and later generalized, together with enlargement of the spleen and often of the liver.
References in periodicals archive ?
Lymph node histology revealed a pleomorphic infiltrate with Reed-Sternberg-like cells suspicious for Hodgkin disease. Following chemotherapy, the patient succumbed to bronchopneumonia.
Lymph node biopsy was suspicious for Hodgkin disease. A faint [Gamma]-heavy-chain spike was identified in serum and urine.
To our knowledge, an association of GHCD with the nodular lymphocyte-predominant form of Hodgkin disease has not been reported previously.
Perhaps more detailed examination of immunoglobulin rearrangements in cases such as ours and the cases reported by Di Benedetto et al[4] and Westin et al[17] may lead to a better understanding of the possible clonal relationship between Hodgkin disease and composite or sequential "non-Hodgkin" B-cell lymphoproliferative processes such as GHCD.
Primary gastrointestinal Hodgkin disease in association with Crohn disease is a rare entity.
Because primary gastrointestinal Hodgkin disease cases are so rare, and those arising in Crohn disease are even rarer, the diagnosis should only be made following strict histologic and other criteria proposed by Dawson et al[10]: (a) no superficial lymphadenopathy should be present at the time of diagnosis; (b) chest radiological studies should indicate no involvement of mediastinal lymph nodes; (c) the complete blood count and white cell differential should be within normal limits; (d) gastrointestinal lesion should predominate with or without positive adjacent lymph nodes; and (e) liver and spleen should be free of disease at the time of diagnosis.
Among the 9 cases described in the literature, 3 reports were published before the advent of newer lymphoma classification systems using modern techniques, such as immunohistochemical studies.[4-6] In 1977, Codling et al[11] reported a case of Hodgkin disease complicating Crohn colitis.
Our case fulfills the criteria of Dawson et al[10] and the immunohistochemical criteria for the diagnosis of primary gastrointestinal Hodgkin disease. The Reed-Sternberg cells and their variants demonstrated a typical immunohistochemical profile (membrane and cytoplasmic staining with dotlike Golgi enhancement of CD30, moderate cytoplasmic staining of CD15 in the Golgi area, diffuse cytoplasmic staining for fascin, focal membrane staining of CD20 of [is less than] 10% of neoplastic cells, and CD45RB and epithelial membrane antigen negativity).
Traditionally, Hodgkin disease has been divided into 4 subtypes based on differences in the appearance of the neoplastic cells, as well as the components of the background.
The presence of infiltration of lymph node sinuses by tumor cells, phagocytosis of neutrophils by tumor cells, and marked anaplasia or the presence of spindle-shaped tumor cells are more common in carcinoma than Hodgkin disease.[3]
Immunohistochemical stains are essential in establishing the correct diagnosis of the syncytial variant of nodular sclerosing Hodgkin disease. Positive Golgi localization staining of the neoplastic cells for CD15 is thought to be characteristic of Hodgkin disease.[4] Additionally, positive staining for CD30 and negative staining for CD45 (leukocyte common antigen) are present.[5] Immunohistochemical stains for cytokeratin and S100 demonstrate lack of staining in the neoplastic cells, which is useful in excluding carcinomas, thymomas, germ cell tumors, and melanomas.
Nodular Sclerosing Hodgkin Disease (HD) and Follicular Small Cleaved Cell (NHL) Composite Lymphomas NHL NHL Age/Sex/Source Site Diagnosis Phenotype 66/F/Jaffe et al(1) Lymph node Follicular B cell (unspecified small cleaved site) type 78/M/present study Lymph node Follicular small B cell (inguinal type cleaved region type HD HD Age/Sex/Source Diagnosis Phenotype 66/F/Jaffe et al(1) Nodular [CD15.sup.+], [L26.sup.-] sclerosis 78/M/present study Nodular [CD15.sup.+], [L26.sup.-], sclerosis [CD30.sup.+]