CYP3A4

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CYP3A4

A gene on chromosome 7q21.1 that encodes a member of the cytochrome P450 superfamily of monooxygenases, which catalyse reactions in drug metabolism and synthesis of cholesterol, steroids and other lipids. CYP3A4 localises to the endoplasmic reticulum; its expression is induced by glucocorticoids and drugs. It metabolises roughly half of the drugs in current use today—e.g., paracetamol (acetaminophen), codeine, cyclosporin A, diazepam and erythromycin—as well as steroids and carcinogens.

CYP3A4

One isoenzyme form of the cytochrome P450 system involved in the metabolism of many drugs. Drugs that alter this enzyme system can influence the metabolism of other agents taken by patients and cause unanticipated toxic effects.
References in periodicals archive ?
Baltimore-based HLP has swiftly moved from being a new idea to a preferred loan-workout solution.
Technology will lead the way in helping servicers more effectively communicate with consumers who want to work out their mortgage situation in a timely manner," said Sanjeev Dahiwadkar, CEO and president of IndiSoft, which provides the technology for HLP.
The Supreme Court finally addressed the HLP's various challenges to the constitutionality of [section] 2339B in HLP VI.
In a vivid illustration that the material support ban is not nearly as clear as Roberts claims, Georgetown law professor David Cole, who represented the HLP before the Supreme Court, pointed out in a January 2011 New York Times op-ed that several hawks in the War on Terror may have unwittingly violated the statute.
The percentage of children with enamel hypoplasia was higher in the CLP group than in the HLP group (29.
We applied multiple stepwise logistic regression analysis to determine the independent risk factors related to the presence of HLP, with adjustments made for age at study enrollment, sex, and anthropometric and biomedical characteristics to prevent confounding bias.
By adopting Faraday's 28nm HLP 7-track miniLib(TM) IP, we optimize chip performance, lower footprint size, and reduce power leakage to achieve low operating temperatures.
HLP is now positioned to serve as a permanent, national mechanism for the entire communication life cycle of any foreclosure-alternative application between consumers, their authorized third parties and mortgage servicers.
Secretary-General Ban Ki Moon, Co-Chair of the Bill & Melinda Gates Foundation, Bill Gates, the President of the Republic of Rwanda, Paul Kagame, British Prime Minister David Cameron, who is one of the HLP's three co-chairs, in addition to HLP member and CEO of Unilever, Paul Polman, and President and CEO of CARE USA, Helen D.
A snsof humoucan hlp softn thosaound you and can also val what ally happnd.
In the first phase of the HLP implementation, the city successfully combined more than $12 million from the Housing Trust Fund with about $75 million in federal, state and private funding.
When lipoproteins fractionated by ultracentrifugation (UC) are assessed by agarose gel electrophoresis (AGE), a population of remnant lipoproteins called [beta]-migrating VLDL ([beta]-VLDL) can be identified in nearly all subjects with type III HLP (1-5).