CYP3A4

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CYP3A4

A gene on chromosome 7q21.1 that encodes a member of the cytochrome P450 superfamily of monooxygenases, which catalyse reactions in drug metabolism and synthesis of cholesterol, steroids and other lipids. CYP3A4 localises to the endoplasmic reticulum; its expression is induced by glucocorticoids and drugs. It metabolises roughly half of the drugs in current use today—e.g., paracetamol (acetaminophen), codeine, cyclosporin A, diazepam and erythromycin—as well as steroids and carcinogens.

CYP3A4

One isoenzyme form of the cytochrome P450 system involved in the metabolism of many drugs. Drugs that alter this enzyme system can influence the metabolism of other agents taken by patients and cause unanticipated toxic effects.
References in periodicals archive ?
HLP became the 'model' portal in that consent order," says Camillo Melchiorre, president and chief executive officer of Baltimore-based HLP Inc.
Mike Harding, principal director of HLP Consulting, added: "Joining PwC is strategically the right choice.
Technology will lead the way in helping servicers more effectively communicate with consumers who want to work out their mortgage situation in a timely manner," said Sanjeev Dahiwadkar, CEO and president of IndiSoft, which provides the technology for HLP.
HLP also groups former German President, Horst Kohler; former Japanese Prime Minister, Naoto Kan; Sweden's Minister for International Development Cooperation, Gunilla Carlsson; co-recipient of the 2011 Nobel Peace Prize, Tawakel Karman of Yemen; Commissioner for Development for the European Commission, Andris Piebalgs and former Director General of the French Development Agency, Jean-Michel Severino.
Around half of the projects HLP completes are for export to support its clients' operations in Australia, Germany, Sweden and Poland, among others.
The same tests were also used to investigate the differences in the OH condition and microbiological parameters between children from the CLP group and HLP group that were undergoing orthodontic treatment.
The HLP logo, a laughing Buddha wearing headphones, seems to illustrate the trio's intent in opening the club.
Baltimore-based HLP has swiftly moved from being a new idea to a preferred loan-workout solution.
HLP Klearfold customers now have a choice of tubular visual packaging systems based on their production requirements, thanks to FILP's acquisition of InSight patents.