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Conclusion: Nearly 23% patients of spondyloarthropathies carry HLA-B27 antigen, with male's predominance (26% vs 16%).
In the present study about 23% patients of SpA were found to be carrying HLA-B27 antigen, with males predominance (26% vs 16%).
Additionally, it is well known that there is a correlation between the HLA-B27 antigen and family aggregation.
2007) [9], in a study of Russian patients, detected a positive association of HLA-B27 antigen with tuberculosis.
3) Up to 85% of patients with Reiter's syndrome possess the HLA-B27 antigen.
Several HLA antigens are associated with various diseases, and probably the strongest association known is that between the HLA-B27 antigen and rheumatic diseases such as ankylosing spondylitis (also known as Bechterew disease), Reiter syndrome, and acute anterior uveitis [1].
Most of the available antibodies are not specific for the HLA-B27 antigen and also react with other HLA-B antigens, notably HLA-B7, B22, and B40.
In the rare case of discordant results (<2%), another method is necessary for definitive typing of the HLA-B27 antigen.
According to HLA tissue typing of the patient, HLA-A1, HLA-A2, HLA-B51, HLA-B44, HLA-BW4, and the HLA-B27 antigen were all negative.
11) The HLA-B27 antigen has been associated with Reiter's syndrome in 63% to 96% of cases in white patients.