human leukocyte antigen

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Related to Hla antigens: Graft versus host disease

human leukocyte antigen (HLA)

any one of four significant histocompatibility antigens governed by genes of the HLA complex, specific loci on chromosome 6, designated HLA-A, HLA-B, HLA-C, and HLA-D. Each locus has several genetically determined alleles; each of these is associated with certain diseases or conditions; for example, HLA-B27 is usually present in people who have ankylosing spondylitis. The HLA system is used to assess tissue compatibility. White blood cells are used for testing. Perfect tissue compatibility exists only between identical twins. See also histocompatibility gene.

human leukocyte antigen (HLA)


hu·man leu·ko·cyte an·ti·gen

(HLA) (hyū'măn lū'kō-sīt an'ti-jen)
Any of several members of a system consisting of the gene products of at least four linked loci (A, B, C, and D) and a number of subloci on the sixth human chromosome that have been shown to have a strong influence on human allotransplantation, transfusions in refractory patients, and some disease associations.


see homo-.

human carriers
humans who act as active carriers of diseases of animals and infect animals.
human immunodeficiency virus
includes HIV1 (more common) and HIV2 which are lentiviruses that cause acquired immunodeficiency disease (AIDS) in humans.
human leukocyte antigen
see major histocompatibility complex.
References in periodicals archive ?
Frequency analysis of HLA antigens in Iranian patients with common variable immunodeficiency.
The patient's serum is incubated with B and T cells from a panel of donors who represent commonly found HLA antigens in the local population.
The virtual crossmatch compares antibody specificity of patients to the HLA antigens of a given donor.
The new policy will require the PRA to be calculated according to a scientifically based formula that uses the frequency of specific, known unacceptable HLA antigens reported for a transplant candidate to determine his or her overall immune sensitivity.
This production of antibodies to the HLA antigens is a reaction that goes essentially unrecognized at the time it is occurring.
Single cord blood transplants are usually done using units that match the recipient for at least six of six HLA antigens.
DNA typing for class II HLA antigens with allele-specific or group-specific amplification.
These HLA antigens give the body's immune system the ability to determine what belongs in the human body and what does not.
It's probably a group of autoimmune disorders: Certain HLA antigens have been associated with it, but no unique infectious stimulus has been identified.