human leukocyte antigen

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Related to Hla antigens: Graft versus host disease

human leukocyte antigen (HLA)


hu·man leu·ko·cyte an·ti·gen

(HLA) (hyū'măn lū'kō-sīt an'ti-jen)
Any of several members of a system consisting of the gene products of at least four linked loci (A, B, C, and D) and a number of subloci on the sixth human chromosome that have been shown to have a strong influence on human allotransplantation, transfusions in refractory patients, and some disease associations.
References in periodicals archive ?
HLA antigen frequencies in end-stage idiopathic and ischaemic cardiomyopathy.
Sensitization to HLA antigens is normally determined by Panel Reactive Antibodies (PRA) which evaluate serum reactivity against the lymphocyte panel of known HLA specificity.
Association of class I HLA antigens with the clinical manifestations of Turkish patients with Behcet's disease.
Traditional PRA assays allow us to estimate the probability of listed patients receiving a graft expressing HLA antigens which the patients are primed against, limiting organ allocation only after a negative CDC prospective crossmatch (usually for patients with PRA > 10%).
Frequency of HLA antigens distribution in patients of group V was equal with those in common form of psoriasis.
The observed frequencies for all HLA antigens and alleles in control group were in accordance with those of a typical Caucasian population (32).
Luminex single-antigen beads coated with HLA antigens (GenProbe, USA) were incubated with recipient sera in a 96-well plate in the dark on a rotating platform.
Objective: The aim of our study was to investigate the association of HLA antigens and a non-HLA protein D8/17 with rheumatic heart disease and its pattern of cardiac involvement.
HLA antigens are encoded for by the major histocompatibility complex (MHC) region of genes on the short arm of chromosome 6 (1).
Nath said, "We try to match all 10 HLA antigens. These days, for 80 percent of Caucasians we do find a match.
HLA antigens in anti-Ro(SS-A)-positive patients with recurrent annular erythema.