Determination of the HIV integrase
inhibitor, MK-0518 (raltegravir), in human plasma J Chromatogr B Analyt Technol Biomed Life Sci, 2007, 857, 15-24.
The chicoric acid appears to disturb this process of HIV integration by halting function of the HIV integrase
, thus preventing HIV from reproducing and infecting other cells, they said.
A research article published in the journal The Lancet reveals that the scientists found that an HIV integrase
inhibitor called Raltegravir is overall as effective as widely used efavirenz, a reverse transcriptase inhibitor.
was recognised as a possible target early in the HIV epidemic , but development of an effective integrase inhibitor was haltingly slow due to issues of potency, protein binding and toxicity.
He also noted that there is now much excitement about HIV integrase
inhibitors, a major target for new drugs.
Scientists have been able to determine the 3-D structure of the complicated molecular core of HIV integrase
IRBM has an outstanding record of drug discovery including Isentress(R), the first approved HIV integrase
inhibitor and winner of the Prix Galien USA 2008 award for the best pharmaceutical agent.
inhibitors: from diketoacids to heterocyclic templates: A history of HIV integrase
medicinal chemistry at Merck West Point and Merck Rome (IRBM) leading to the discovery of raltegravir
This INI's mechanism of action involves inhibiting the catalytic activity of HIV integrase
, an enzyme that is required for viral replication, which blocks HIV from integrating its DNA into the host cell genome.
Human Immunodeficiency Virus HIV Protease Inhibitors HIV Non-nucleoside Reverse Transcriptase Inhibitors HIV Nucleoside Reverse Transcriptase Inhibitors HIV Entry Inhibitors HIV Integrase
Inhibitors Hepatitis C Virus Protease Inhibitors HCV Polymerase Nucleoside Inhibitors Other HCV Inhibitors Respiratory Syncytial Virus Inhibitors Influenza, Hepatitis B, and Cytomegalovirus Inhibitors
572-Trii's mechanism of action involves the following - - Dolutegravir, as an integrase inhibitor, targets HIV integrase
, an enzyme that is required for the integration of viral DNA into the host cell genome.
The drug is part of a class of medications called HIV integrase
strand transfer inhibitors that works by slowing the spread of HIV in the body.