Identification of a small molecule binding site at the dimer interface of the HIV integrase
Determination of the HIV integrase
inhibitor, MK-0518 (raltegravir), in human plasma J Chromatogr B Analyt Technol Biomed Life Sci, 2007, 857, 15-24.
has completed the Phase II clinical trial of GS 9137, a novel oral HIV integrase
Iin fact, the strengthening of Avexa's internal clinical capabilities will complement the clinical phases of these programs, in particular Avexa's HIV integrase
According to Krause, the problem with finding an inhibitor for HIV integrase
inhibitors with antiviral action are actively being studied.
The acid, which is identical to substances used by Bolivian shamans in medicinal plants, stops one of three key enzymes called HIV integrase
from promoting the infection, the researchers said.
Years later, Merck scientists were the first to demonstrate inhibition of HIV integrase
in vitro and in vivo.
A research article published in the journal The Lancet reveals that the scientists found that an HIV integrase
inhibitor called Raltegravir is overall as effective as widely used efavirenz, a reverse transcriptase inhibitor.
was recognised as a possible target early in the HIV epidemic , but development of an effective integrase inhibitor was haltingly slow due to issues of potency, protein binding and toxicity.
Among the new classes of drugs under study are HIV integrase
inhibitors, which block the enzyme that HIV uses to incorporate its genetic material into human DNA, and HIV entry inhibitors, which prevent the virus from entering the cell.
He also noted that there is now much excitement about HIV integrase
inhibitors, a major target for new drugs.