Histoplasma capsulatum


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His·to·plas·ma cap·su·la·tum

(his'tō-plaz'mă kap'sū-lā'tŭm),
A dimorphic fungus species of worldwide distribution that causes histoplasmosis in humans and other mammals; its ascomycetous state is Ajellomyces capsulatum. The organism's natural habitat is soil fertilized with bird and bat droppings, where it grows as a mold, fragments of which, following inhalation, produce the primary pulmonary infection; within the mammalian host tissues, inhaled mycelial fragments grow as uninuclear yeasts that reproduce by budding. This parasitic form may also be induced in the laboratory by culturing the mycelial phase at 37°C on a blood-enriched medium; growth reverts to the mycelial form when the temperature is below 37°C. Histoplasma capsulatum var. duboisii causes a clinically distinct disease, African histoplasmosis, in which large yeast cells with thicker walls are found in tissues, in contrast to the small yeast cells of Histoplasma capsulatum var. farciminosum, which causes epizootic lymphangitis.
[histo- + G. plasma, something formed]
Farlex Partner Medical Dictionary © Farlex 2012

His·to·plas·ma cap·su·la·tum

(his'tō-plaz'mă kap-sū-lā'tŭm)
A dimorphic fungus species that causes histoplasmosis; its ascomycetous state is Ajellomyces capsulatum. The organism's natural habitat is soil fertilized with bird and bat droppings, where it grows as a mold, fragments of which, following inhalation, produce the primary pulmonary infection; within the mammalian host, inhaled mycelial fragments grow as uninuclear yeasts that reproduce by budding. H. capsulatum is encountered primarily in Africa and in North America.
[histo- + G. plasma, something formed]
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
References in periodicals archive ?
Environmental factors and growth of Histoplasma capsulatum in soil.
Entre las regiones con mayor prevalencia se encuentran el Caribe y America Latina, y el principal patogeno involucrado es Histoplasma capsulatum variedad capsulatum.
Etiology Frequency Infectious (11) Staphylococcus aureus 4 (2 MSSA; 2 MRSA) Histoplasma capsulatum 2 Mycoplasma pneumoniae 2 Enterovirus 1 Influenza A 1 Purulent (negative cultures) 1 Non-Infectious (21) Systemic lupus erythematosus 5 Juvenile idiopathic arthritis 2 Undetermined inflammatory cause 2 B-cell non-Hodgkin's lymphoma 1 Epicardial xanthogranuloma 1 Cardiomyopathy 2 Undetermined (2 with underlying malignancy) 6 Total 32 MSSA: methicillin-susceptible Staphylococcus aureus.
Cheng, "Histoplasma capsulatum infection associated with continuous ambulatory peritoneal dialysis," Infection, vol.
Human infections caused by Histoplasma capsulatum may present as acute pulmonary histoplasmosis, chronic pulmonary histoplasmosis, and progressive disseminated histoplasmosis.
Histoplasmosis is a fungal infection resulting from the inhalation of spores of the fungus Histoplasma capsulatum which is endemic to the Ohio and Mississippi river valleys in the United States and also to Mexico and Central and South America.
Serum and urine Histoplasma capsulatum antigens maybe negative even in the setting of active infection, and there is limited data on the duration of treatment for patients who remain immunocompromised.
The presence of growth-promoting factors in birds' excrement in the soil of places where birds are found in a large number serves as an excellent niche for these fungi, particularly human pathogenic fungi like Histoplasma capsulatum, Cryptococcus neoformans, Aspergillus (A.), Candida species (spp.), etc.
Basic Local Alignment Search Tool (BLAST) revealed 93% identity with Hsp60 from Blastomyces dermatitidis and Histoplasma capsulatum, and 89 and 81% with Hsp60 from Aspergillus fumigatus and Sporothrix schenckii, respectively (data not shown).
Diagnosis of this disorder is based upon characteristic clinical findings and a positive histoplasmin skin test or residence in an endemic region for Histoplasma capsulatum. There is no active systemic disease during diagnosis of POHS.
Isolation of Histoplasma capsulatum from tissues of bats captured in the Aguas Buenas caves, Aguas Buenas, Puerto Rico.
Sobreira et al., "Antibody binding alters the characteristics and contents of extracellular vesicles released by Histoplasma capsulatum," mSphere, vol.