KAT2A

(redirected from Histone acetyltransferase GCN5)

KAT2A

A gene on chromosome 17q12-q21 that encodes a ubiquitously expressed histone acetyltransferase, which acts primarily as a transcriptional activator. KAT2A also downregulates NF-kappB by promoting ubiquitination of the NF-kappB subunit RELA in a HAT-independent manner. It is recruited by HIV-1’s viral Tat protein, regulates Tat's transactivating activity, and may help induce chromatin remodelling of proviral genes.
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References in periodicals archive ?
In a similar sex-specific manner, arsenic exposure increased H3K9ac and the histone acetyltransferase GCN5 in the DG, whereas H3K9ac (KE7) and GCN5 (KE8) were decreased in the FC of male mice.
Zhou, "Histone acetyltransferase GCN5 regulates osteogenic differentiation of mesenchymal stem cells by inhibiting NF-[kappa]B," Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research, vol.