HDAC3

(redirected from Histone Deacetylase 3)
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HDAC3

A gene on chromosome 5q31 that encodes histone deacetylase 3; it belongs to the histone deacetylase/acuc/apha family, which represses transcription when tethered to a promoter and may regulate transcription by binding with the zinc-finger transcription factor YY1. HDAC3 downregulates p53 activity and thus modulates cell growth and apoptosis; it may be a tumour suppressor gene.
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Alenghat et al., "Histone deacetylase 3 is an epigenomic brake in macrophage alternative activation," Genes and Development, vol.
Stengel et al., "Inhibition of histone deacetylase 3 causes replication stress in cutaneous T cell lymphoma," PLoS ONE, vol.
Haberland et al., "Maintenance of cardiac energy metabolism by histone deacetylase 3 in mice," The Journal of Clinical Investigation, vol.
Epstein, "Histone deacetylase 3 regulates smooth muscle differentiation in neural crest cells and development of the cardiac outflow tract," Circulation Research, vol.
London, May 7 ( ANI ): In a new study, researchers have found that mice in which an enzyme called histone deacetylase 3 (HDAC3) is deleted, have massively fatty livers, but lower blood sugar, and are thus protected from glucose intolerance and insulin resistance, the hallmark of diabetes.
Another team member, called histone deacetylase 3 (HDAC3), does construction work on the protein scaffold (the epigenome) surrounding the genome to dampen the activity of the fat-related genes.

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