histocompatibility antigens


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histocompatibility antigens

Genetically determined glycoprotein groups situated on the outer membrane of all body cells to provide an identifying code unique for each person (except identical twins). These groups act as antigens and, in a foreign environment, provoke the production of antibodies against them. This is the basis of graft rejection. They are also called HLA antigens because they were first found on human white blood cells (leukocytes). There are three classes: class 1proteins are found on the surface of most cells, even on red blood cells; class 2 proteins are found on the surface of B cells, antigen-presenting cells and some endothelial cells; class 3 proteins are components of the complement system. See also MAJOR HISTOCOMPATIBILITY COMPLEX (MHC).

Histocompatibility antigens

Proteins scattered throughout body tissues that are unique for almost every individual.
References in periodicals archive ?
Hodes et al., "Minor histocompatibility antigens are expressed in syncytiotrophoblast and trophoblast debris: implications for maternal alloreactivity to the fetus," The American Journal of Pathology, vol.
The contract is for the supply of reagents and consumables for typing histocompatibility antigens PCR SSO for the KLA in quantity, range and requirements set out in Appendix 5 hereto.
It is widely accepted that the disease occurs secondary to a dominant gene that shows poor penetrance and is intimately linked to histocompatibility antigens HLA-A3, HLA-B7, and HLA-B14.